Progression of dopaminergic depletion in a model of MPTP-induced Parkinsonism in non-human primates. An F-18-DOPA and C-11-DTBZ PET study

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dc.contributor.authorBlesa, Javier
dc.contributor.authorJuri, Carlos
dc.contributor.authorCollantes, Maria
dc.contributor.authorPenuelas, Ivan
dc.contributor.authorPrieto, Elena
dc.contributor.authorIglesias, Elena
dc.contributor.authorMarti Climent, Josep
dc.contributor.authorArbizu, Javier
dc.contributor.authorZubieta, Jose L.
dc.contributor.authorCruz Rodriguez Oroz, Mari
dc.contributor.authorGarcia Garcia, David
dc.contributor.authorRichter, Jose A.
dc.contributor.authorCavada, Carmen
dc.contributor.authorObeso, Jose A.
dc.date.accessioned2024-01-10T12:41:50Z
dc.date.available2024-01-10T12:41:50Z
dc.date.issued2010
dc.description.abstractDopaminergic depletion in the nigrostriatal system is the neurochemical hallmark of Parkinson's disease (PD). Although numerous efforts have been made to determine the evolution of dopaminergic depletion in PD, "in vivo" data concerning the stages of this process are still scarce. We evaluated 6-[18F]-fluoro-L-DOPA (F-18-DOPA) and 11C-(+)-alpha-dihydrotetrabenazine (C-11-DTBZ) using PET in a model of chronically MFTP-induced parkinsonism in non-human primates. Methods: Sixty-seven cynomolgus monkeys (Macaca fascicularis) were included in the study. Progressive parkinsonism was induced by repeated administration of small doses of MPTP (iv) over several months. Animals were classified as controls, asymptomatic, recovered (having exhibited parkinsonian features transiently) and stable parkinsonian, according to their motor status. Analysis of striatal dopaminergic activity was conducted by regions of interest (ROI) and statistical parametric mapping (SPM) over normalized parametric images. Results: A progressive loss of striatal uptake was evident among groups for both radiotracers, which correlated significantly with the clinical motor status. Changes occurred earlier, i.e. in the less affected stages, with C-11-DTBZ. Similar results were achieved by ROI and SPM analysis. Uptake was similar with both radiotracers for the asymptomatic and recovered groups. Conclusions: Serial assessment with F-18-DOPA and C-11-DTBZ PETs provides an effective approach to evaluate evolution of dopaminergic depletion in monkeys with MPTP-induced parkinsonism. This approach could be useful to perform studies aiming to test the effect of early therapeutic intervention and putative neuroprotective treatments. (C) 2010 Elsevier Inc. All rights reserved.
dc.description.funderPlan Nacional de Investigacion
dc.description.funderMinisterio de Investigacion y Ciencia
dc.description.funderUniversity of Navarra
dc.description.funderALBAN
dc.description.funderEuropean Union
dc.fechaingreso.objetodigital03-04-2024
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.nbd.2010.03.006
dc.identifier.issn0969-9961
dc.identifier.pubmedidMEDLINE:20304066
dc.identifier.urihttps://doi.org/10.1016/j.nbd.2010.03.006
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77456
dc.identifier.wosidWOS:000277648200016
dc.information.autorucMedicina;Juri C;S/I;7476
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final463
dc.pagina.inicio456
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.revistaNEUROBIOLOGY OF DISEASE
dc.rightsacceso restringido
dc.subjectPET
dc.subjectParkinson's disease
dc.subjectMPTP-induced parkinsonism
dc.subjectNon-human primates
dc.subjectPOSITRON-EMISSION-TOMOGRAPHY
dc.subjectDISEASE
dc.subjectMONKEYS
dc.subjectPATTERN
dc.subjectBINDING
dc.subjectVMAT2
dc.subjectROPINIROLE
dc.subjectSTRIATUM
dc.subjectLEVODOPA
dc.subjectDOPA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleProgression of dopaminergic depletion in a model of MPTP-induced Parkinsonism in non-human primates. An F-18-DOPA and C-11-DTBZ PET study
dc.typeartículo
dc.volumen38
sipa.codpersvinculados7476
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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