Neutral endopeptidase and angiotensin I converting enzyme insertion/deletion gene polymorphism in humans

Braun, S.; Chamorro, G.; Córdova, S.; Fardella, C.; Godoy, I.; Jalil, J.E.; Lavandero, S.; Michel, J-B.; Oliveri, C.; Ocaranza Jeraldino, María Paz

Neutral endopeptidase and angiotensin I converting enzyme insertion/deletion gene polymorphism in humans

Date

2004

Authors

Ocaranza Jeraldino, María Paz

Abstract

Neutral endopeptidase (NEP) hydrolyses angiotensins (Ang) I and II and generates angiotensin-(1-7) [Ang-(17)]. In humans, the insertion/deletion (I/D) angiotensin- I converting enzyme ( ACE) gene polymorphism determined plasma ACE levels by 40%. In rats,