The interplay between leptin, glucocorticoids, and GLP1 regulates food intake and feeding behaviour

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dc.catalogadorjca
dc.contributor.authorPerez‐Leighton, Claudio
dc.contributor.authorKerr, Bredford
dc.contributor.authorScherer, Philipp E.
dc.contributor.authorBaudrand, René
dc.contributor.authorCortés, Víctor
dc.date.accessioned2024-02-27T16:02:48Z
dc.date.available2024-02-27T16:02:48Z
dc.date.issued2023
dc.description.abstractNutritional, endocrine, and neurological signals converge in multiple brain centres to control feeding behaviour and food intake as part of the allostatic regulation of energy balance. Among the several neuroendocrine systems involved, the leptin, glucocorticoid, and glucagon-like peptide 1 (GLP1) systems have been extensively researched. Leptin is at the top hierarchical level since its complete absence is sufficient to trigger severe hyperphagia. Glucocorticoids are key regulators of the energy balance adaptation to stress and their sustained excess leads to excessive adiposity and metabolic perturbations. GLP1 participates in metabolic adaptation to food intake, regulating insulin secretion and satiety by parallel central and peripheral signalling systems. Herein, we review the brain and peripheral targets of these three hormone systems that integrate to regulate food intake, feeding behaviour, and metabolic homeostasis. We examine the functional relationships between leptin, glucocorticoids, and GLP1 at the central and peripheral levels, including the cross-regulation of their circulating levels and their cooperative or antagonistic actions at different brain centres. The pathophysiological roles of these neuroendocrine systems in dysregulated intake are explored in the two extremes of body adiposity – obesity and lipodystrophy – and eating behaviour disorders.
dc.fuente.origenORCID
dc.identifier.doi10.1111/brv.13039
dc.identifier.issn1469-185X
dc.identifier.urihttps://doi.org/10.1111/brv.13039
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81349
dc.information.autorucFacultad de Ciencias Biológicas;Perez‐Leighton, Claudio;0000-0003-1817-6314;126972
dc.information.autorucEscuela de Medicina;Baudrand Biggs, René;0000-0002-8655-4957;1024
dc.information.autorucEscuela de Medicina; Cortes Mora, Victor Antonio; 0000-0002-1658-0965; 7576
dc.language.isoen
dc.nota.accesoContenido parcial
dc.revistaBiological Reviews
dc.rightsacceso restringido
dc.subjectFood intake
dc.subjectAppetite
dc.subjectEating behaviour
dc.subjectLeptin
dc.subjectGlucocorticoid
dc.subjectGlucagon-like peptide-1
dc.subjectObesity
dc.subjectLipodystrophy
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleThe interplay between leptin, glucocorticoids, and GLP1 regulates food intake and feeding behaviour
dc.typeartículo
sipa.codpersvinculados126972
sipa.codpersvinculados1024
sipa.codpersvinculados7576
sipa.trazabilidadORCID;2024-01-15
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