Myth: Gastroesophageal reflux is a pathological entity in the preterm infant

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dc.contributor.authorPoets, Christian F.
dc.contributor.authorBrockmann, Pablo E.
dc.date.accessioned2024-01-10T13:15:18Z
dc.date.available2024-01-10T13:15:18Z
dc.date.issued2011
dc.description.abstractThere is concern about possible consequences of gastroesophageal reflux (GER) in preterm infants. GER is perceived to be a frequent condition in these infants, often causing an exhaustive investigation and expensive therapy. We review current evidence for and against an association between GER and apnea, failure to thrive, wheezing and respiratory diseases. Although there are some limitations to the methodologies currently used for detecting GER, there is clearly a lack of unequivocal evidence supporting a causal relationship between GER and its assumed consequences, particularly in preterm infants. Despite physiologic data that stimulation of laryngeal efferents by GER may induce apnea, there is little evidence for a causal relationship between GER and apnea. Studies on preterm infants with failure to thrive have also not demonstrated an association between the latter and GER in most cases, and there is equally little evidence for a casual relationship with respiratory problems. Therefore, we believe that GER in preterm infants is only rarely associated with serious consequences and existing evidence does not support the widespread use of anti-reflux medications for treatment of these signs in this age group. An improvement of methods to identify the few preterm infants at risk for developing serious consequences of GER is urgently needed. (C) 2011 Published by Elsevier Ltd.
dc.fechaingreso.objetodigital09-04-2024
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.siny.2011.05.001
dc.identifier.eissn1878-0946
dc.identifier.issn1744-165X
dc.identifier.pubmedidMEDLINE:21664203
dc.identifier.urihttps://doi.org/10.1016/j.siny.2011.05.001
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78490
dc.identifier.wosidWOS:000294398900005
dc.information.autorucMedicina;Brockmann P;S/I;16588
dc.issue.numero5
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final263
dc.pagina.inicio259
dc.publisherELSEVIER SCI LTD
dc.revistaSEMINARS IN FETAL & NEONATAL MEDICINE
dc.rightsacceso restringido
dc.subjectApnea of prematurity
dc.subjectLower esophageal sphincter
dc.subjectRegurgitation
dc.subjectTreatment indications
dc.subjectMULTIPLE INTRALUMINAL IMPEDANCE
dc.subjectFAT-LADEN MACROPHAGES
dc.subjectBIRTH-WEIGHT INFANTS
dc.subjectESOPHAGEAL REFLUX
dc.subjectPREMATURE-INFANTS
dc.subjectPH-METRY
dc.subjectAPNEA
dc.subjectSLEEP
dc.subjectDISEASE
dc.subjectBRADYCARDIA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMyth: Gastroesophageal reflux is a pathological entity in the preterm infant
dc.typeartículo
dc.volumen16
sipa.codpersvinculados16588
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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