Hypoglycemia and glycemic variability of people with type 1 diabetes with lower and higher physical activity loads in free-living conditions using continuous subcutaneous insulin infusion with predictive low-glucose suspend system

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dc.article.numbere003082
dc.catalogadorgjm
dc.contributor.authorMontt Blanchard, Denise
dc.contributor.authorSánchez, Raimundo
dc.contributor.authorDubois Camacho, Karen
dc.contributor.authorLeppe, Jaime
dc.contributor.authorOnetto Flores, María Teresa
dc.date.accessioned2024-05-15T20:24:30Z
dc.date.available2024-05-15T20:24:30Z
dc.date.issued2023
dc.description.abstractIntroduction Maintaining glycemic control during and after physical activity (PA) is a major challenge in type 1 diabetes (T1D). This study compared the glycemic variability and exercise-related diabetic management strategies of adults with T1D achieving higher and lower PA loads in nighttime-daytime and active- sedentary behavior hours in free-living conditions., Research design and methods Active adults (n=28) with T1D (ages: 35 +/- 10 years; diabetes duration: 21 +/- 11 years; body mass index: 24.8 +/- 3.4 kg/m(2); glycated hemoglobin A1c: 6.9 +/- 0.6%) on continuous subcutaneous insulin delivery system with predictive low glucose suspend system and glucose monitoring, performed different types, duration and intensity of PA under free-living conditions, tracked by accelerometer over 14 days. Participants were equally divided into lower load (LL) and higher load (HL) by median of daily counts per minute (61122). Glycemic variability was studied monitoring predefined time in glycemic ranges (time in range (TIR), time above range (TAR) and time below range (TBR)), coefficient of variation (CV) and mean amplitude of glycemic excursions (MAGE). Parameters were studied in defined hours timeframes (nighttime-daytime and active-sedentary behavior). Self-reported diabetes management strategies were analysed during and post-PA., Results Higher glycemic variability (CV) was observed in sedentary hours compared with active hours in the LL group (p <= 0.05). HL group showed an increment in glycemic variability (MAGE) during nighttime versus daytime (p <= 0.05). There were no differences in TIR and TAR across all timeframes between HL and LL groups. The HL group had significantly more TBR during night hours than the LL group (p <= 0.05). Both groups showed TBR above recommended values. All participants used fewer post-PA management strategies than during PA (p <= 0.05)., Conclusion Active people with T1D are able to maintain glycemic variability, TIR and TAR within recommended values regardless of PA loads. However, the high prevalence of TBR and the less use of post-PA management strategies highlights the potential need to increase awareness on actions to avoid glycemic excursions and hypoglycemia after exercise completion.
dc.description.funderExternal Research Program of Medtronic
dc.fechaingreso.objetodigital2024-05-15
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1136/bmjdrc-2022-003082
dc.identifier.eissn2052-4897
dc.identifier.urihttps://doi.org/10.1136/bmjdrc-2022-003082
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/85690
dc.identifier.wosidWOS:000968080300003
dc.information.autorucEscuela de Diseño; Montt Blanchard, Denise; 0000-0001-6558-4113; 1616
dc.information.autorucEscuela de Medicina; Onetto Flores, María Teresa; S/I; 1124999
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaBMJ Open Diabetes Research & Care
dc.rightsacceso abierto
dc.rights.licenseCC BY-NC 4.0 DEED Atribución-NoComercial 4.0 Internacional
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectExercise
dc.subjectDiabetes mellitus
dc.subjectType 1
dc.subjectHyperglycemia
dc.subjectHypoglycemia
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHypoglycemia and glycemic variability of people with type 1 diabetes with lower and higher physical activity loads in free-living conditions using continuous subcutaneous insulin infusion with predictive low-glucose suspend system
dc.typeartículo
dc.volumen11
sipa.codpersvinculados1616
sipa.codpersvinculados1124999
sipa.trazabilidadWOS;2023-07-06
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