Clinical and pulmonary function analysis in long-COVID revealed that long-term pulmonary dysfunction is associated with vascular inflammation pathways and metabolic syndrome

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dc.catalogadorpau
dc.contributor.authorSanhueza, Sergio
dc.contributor.authorVidal, Mabel A.
dc.contributor.authorHernandez, Mauricio A.
dc.contributor.authorHenriquez-Beltran, Mario E.
dc.contributor.authorCabrera, Camilo
dc.contributor.authorQuiroga, Romina
dc.contributor.authorAntilef, Barbara E.
dc.contributor.authorAguilar, Kevin P.
dc.contributor.authorCastillo, Daniela A.
dc.contributor.authorLlerena, Faryd J.
dc.contributor.authorFigueroa, Marco Fraga
dc.contributor.authorNazal, Mauricio
dc.contributor.authorCastro, Eritson
dc.contributor.authorLagos, Paola
dc.contributor.authorMoreno, Alexa
dc.contributor.authorLastra, Jaime J.
dc.contributor.authorGajardo, Jorge
dc.contributor.authorGarces, Pamela
dc.contributor.authorRiffo, Benilde
dc.contributor.authorBuchert, Jorge
dc.contributor.authorSanhueza, Rocio
dc.contributor.authorOrmazaba, Valeska
dc.contributor.authorSaldivia, Pablo
dc.contributor.authorVargas, Cristian
dc.contributor.authorNourdin, Guillermo
dc.contributor.authorKoch, Elard
dc.contributor.authorZuniga, Felipe A.
dc.contributor.authorLamperti, Liliana
dc.contributor.authorBustos, Paula
dc.contributor.authorGuzman-Gutierrez, Enrique
dc.contributor.authorTapia, Claudio A.
dc.contributor.authorFerrada, Luciano
dc.contributor.authorCerda, Gustavo
dc.contributor.authorWoehlbier, Ute
dc.contributor.authorRiquelme, Marcelo
dc.contributor.authorYuseff, Maria Isabel
dc.contributor.authorRamirez, Braulio A. Munoz
dc.contributor.authorLombardi, Giovanna
dc.contributor.authorDe Gonzalo-Calvo, David
dc.contributor.authorSalomon, Carlos
dc.contributor.authorVerdugo, Ricardo A.
dc.contributor.authorQuinones, Luis A.
dc.contributor.authorColombo, Alicia
dc.contributor.authorBarria, Maria I.
dc.contributor.authorLabarca, Gonzalo
dc.contributor.authorNova-Lamperti, Estefania
dc.date.accessioned2024-07-19T18:35:52Z
dc.date.available2024-07-19T18:35:52Z
dc.date.issued2023
dc.description.abstractIntroduction: Long-term pulmonary dysfunction (L-TPD) is one of the most critical manifestations of long-COVID. This lung affection has been associated with disease severity during the acute phase and the presence of previous comorbidities, however, the clinical manifestations, the concomitant consequences and the molecular pathways supporting this clinical condition remain unknown. The aim of this study was to identify and characterize L-TPD in patients with long-COVID and elucidate the main pathways and long-term consequences attributed to this condition by analyzing clinical parameters and functional tests supported by machine learning and serum proteome profiling. Methods: Patients with L-TPD were classified according to the results of their computer-tomography (CT) scan and diffusing capacity of the lungs for carbon monoxide adjusted for hemoglobin (DLCOc) tests at 4 and 12-months post-infection. Results: Regarding the acute phase, our data showed that L-TPD was favored in elderly patients with hypertension or insulin resistance, supported by pathways associated with vascular inflammation and chemotaxis of phagocytes, according to computer proteomics. Then, at 4-months post-infection, clinical and functional tests revealed that L-TPD patients exhibited a restrictive lung condition, impaired aerobic capacity and reduced muscular strength. At this time point, high circulating levels of platelets and CXCL9, and an inhibited FCgamma-receptor-mediated-phagocytosis due to reduced Fc gamma RIII (CD16) expression in CD14+ monocytes was observed in patients with L-TPD. Finally, 1-year post infection, patients with L-TPD worsened metabolic syndrome and augmented body mass index in comparison with other patient groups. Discussion: Overall, our data demonstrated that CT scan and DLCOc identified patients with L-TPD after COVID-19. This condition was associated with vascular inflammation and impair phagocytosis of virus-antibody immune complexes by reduced Fc gamma RIII expression. In addition, we conclude that COVID-19 survivors required a personalized follow-up and adequate intervention to reduce long-term sequelae and the appearance of further metabolic diseases.
dc.fechaingreso.objetodigital2024-07-19
dc.format.extent21 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3389/fmed.2023.1271863
dc.identifier.eissn2296-858X
dc.identifier.urihttps://doi.org/10.3389/fmed.2023.1271863
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87181
dc.identifier.wosidWOS:001085988800001
dc.information.autorucEscuela de Medicina; Riquelme, Marcelo; 0000-0002-2696-7995; 1001194
dc.information.autorucFacultad de Ciencias Biológicas; Yuseff, Maria Isabel; 0000-0001-8172-3785; 229802
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherFRONTIERS MEDIA SA
dc.revistaFRONTIERS IN MEDICINE
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 ATTRIBUTION 4.0 INTERNATIONAL
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCOVID-19
dc.subjectPulmonary dysfunction
dc.subjectSequelae
dc.subjectChemokines
dc.subjectVascular inflammation
dc.subjectMetabolic syndrome
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleClinical and pulmonary function analysis in long-COVID revealed that long-term pulmonary dysfunction is associated with vascular inflammation pathways and metabolic syndrome
dc.typeartículo
dc.volumen10
sipa.codpersvinculados1001194
sipa.codpersvinculados229802
sipa.trazabilidadWOS;2023-11-04
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