Simultaneous comprehensive liver T1, T2, , T1ρ, and fat fraction characterization with MR fingerprinting

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dc.catalogadorgjm
dc.contributor.authorVelasco, Carlos
dc.contributor.authorCruz, Gastão
dc.contributor.authorJaubert, Olivier
dc.contributor.authorLavin, Begoña
dc.contributor.authorBotnar, René Michael
dc.contributor.authorPrieto Vásquez, Claudia
dc.date.accessioned2024-01-30T15:23:31Z
dc.date.available2024-01-30T15:23:31Z
dc.date.issued2022
dc.description.abstractPurpose: To develop a novel simultaneous co-registered T1, T2, urn:x-wiley:07403194:media:mrm29089:mrm29089-math-0811, T1ρ, and fat fraction abdominal MR fingerprinting (MRF) approach for fully comprehensive liver-tissue characterization in a single breath-hold scan. Methods: A gradient-echo liver MRF sequence with low fixed flip angle, multi-echo radial readout, and varying magnetization preparation pulses for multiparametric encoding is performed at 1.5 T. The urn:x-wiley:07403194:media:mrm29089:mrm29089-math-0011 and fat fraction are estimated from a graph/cut water/fat separation method using a six-peak fat model. Water/fat singular images obtained are then matched to an MRF dictionary, estimating water-specific T1, T2, and T1ρ. The proposed approach was tested in phantoms and 10 healthy subjects and compared against conventional sequences. Results: For the phantom studies, linear fits show excellent coefficients of determination (r2 > 0.9) for every parametric map. For in vivo studies, the average values measured within regions of interest drawn on liver, spleen, muscle, and fat are statistically different from the reference scans (p < 0.05) for T1, T2, and T1⍴ but not for urn:x-wiley:07403194:media:mrm29089:mrm29089-math-0012 and fat fraction, whereas correlation between MRF and reference scans is excellent for each parameter (r2 > 0.92 for every parameter). Conclusion: The proposed multi-echo inversion-recovery, T2, and T1⍴ prepared liver MRF sequence presented in this work allows for quantitative T1, T2, urn:x-wiley:07403194:media:mrm29089:mrm29089-math-0013, T1⍴, and fat fraction liver-tissue characterization in a single breath-hold scan of 18 seconds. The approach showed good agreement and correlation with respect to reference clinical maps.
dc.fechaingreso.objetodigital2024-06-05
dc.fuente.origenORCID
dc.identifier.doi10.1002/mrm.29089
dc.identifier.urihttps://doi.org/10.1002/mrm.29089
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81073
dc.information.autorucEscuela de Ingeniería; Botnar, René Michael; 0000-0002-9447-4367; 1015313
dc.information.autorucEscuela de Ingeniería; Prieto Vásquez, Claudia; 0000-0003-4602-2523; 14195
dc.language.isoen
dc.nota.accesoContenido completo
dc.rightsacceso abierto
dc.subjectT∗2 mapping
dc.subjectLiver MRI
dc.subjectMagnetic resonance fingerprinting
dc.subjectMultiparametric
dc.subjectT1⍴ mapping
dc.subjectT1 mapping
dc.subjectT2 mapping
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleSimultaneous comprehensive liver T1, T2, , T1ρ, and fat fraction characterization with MR fingerprinting
dc.typeartículo
sipa.codpersvinculados1015313
sipa.codpersvinculados14195
sipa.trazabilidadORCID;2024-01-15
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