Influence of extrahepatic viral infection on the natural history of hepatitis C

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dc.contributor.authorInes Barria, Maria
dc.contributor.authorVera Otarola, Jorge
dc.contributor.authorLeon, Ursula
dc.contributor.authorVollrath, Valeska
dc.contributor.authorMarsac, Delphine
dc.contributor.authorRiquelme, Arnoldo
dc.contributor.authorLopez Lastra, Marcelo
dc.contributor.authorSoza, Alejandro
dc.date.accessioned2024-01-10T13:49:26Z
dc.date.available2024-01-10T13:49:26Z
dc.date.issued2008
dc.description.abstractHCV is primarily hepatotropic, but there is mounting evidence pointing to infection and replication of extrahepatic sites. Here we evaluated the occurrence of HCV infection of peripheral blood mononuclear cells (PBMC) and explored the possible association between viral extrahepatic infection and the natural history of the disease. Forty seven Chilean, HCV infected, treatment naive patients were included in the study. HCV RNA was isolated from plasma and PBMC and subsequently reverse transcribed, amplified and sequenced. Most patients harbored HCV 1b genotype and the most common route of infection showed to be blood transfusion. HCV RNA was readily detected in PBMCs of 34 out of the 47 patients (72%). We report that HCV sequences found in PBMC differ from those in plasma of the same subjects strongly suggesting HCV compartmentalization. In addition, we found that patients with detectable HCV RNA in PBMC had a tendency for being more likely cirrhotic [OR 3.8 (95 % CI: 0.98 to 14)]. In conclusion, this study provides further arguments for the existence of HCV infection of extrahepatic sites and suggests that extrahepatic infection could be a factor influencing the natural history of the disease.
dc.fechaingreso.objetodigital2024-06-25
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.issn1665-2681
dc.identifier.pubmedidMEDLINE:18626431
dc.identifier.urihttps://doi.org/10.1016/S1665-2681(19)31869-1
dc.identifier.wosidWOS:000256898100006
dc.information.autorucCiencias Biológicas;Barría M;S/I;12076
dc.information.autorucMedicina;León U;S/I;1005748
dc.information.autorucMedicina;López-Lastra M;S/I;84823
dc.information.autorucMedicina;Marsac D;S/I;146335
dc.information.autorucMedicina;Riquelme A;S/I;3538
dc.information.autorucMedicina;Soza A;S/I;461
dc.information.autorucCiencias Biológicas;Vollrath V;S/I;2185
dc.issue.numero2
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final143
dc.pagina.inicio136
dc.publisherELSEVIER ESPANA
dc.revistaANNALS OF HEPATOLOGY
dc.rightsacceso abierto
dc.subjectcirrhosis
dc.subjectfibrosis
dc.subjectliver
dc.subjectquasiespecies
dc.subjectBLOOD MONONUCLEAR-CELLS
dc.subjectVIRUS-RNA
dc.subjectMIXED CRYOGLOBULINEMIA
dc.subjectHCV-RNA
dc.subjectCEREBROSPINAL-FLUID
dc.subjectBONE-MARROW
dc.subjectSERUM
dc.subjectREPLICATION
dc.subjectLIVER
dc.subjectMANIFESTATIONS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleInfluence of extrahepatic viral infection on the natural history of hepatitis C
dc.typeartículo
dc.volumen7
sipa.codpersvinculados12076
sipa.codpersvinculados1005748
sipa.codpersvinculados84823
sipa.codpersvinculados146335
sipa.codpersvinculados3538
sipa.codpersvinculados461
sipa.codpersvinculados2185
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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