Quantitative CT Measurement of Cross-sectional Area of Small Pulmonary Vessel in COPD: Correlations with Emphysema and Airflow Limitation

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dc.contributor.authorMatsuoka, Shin
dc.contributor.authorWashko, George R.
dc.contributor.authorDransfield, Mark T.
dc.contributor.authorYamashiro, Tsuneo
dc.contributor.authorEstepar, Raul San Jose
dc.contributor.authorDiaz, Alejandro
dc.contributor.authorSilverman, Edwin K.
dc.contributor.authorPatz, Samuel
dc.contributor.authorHatabu, Hiroto
dc.date.accessioned2024-01-10T13:16:56Z
dc.date.available2024-01-10T13:16:56Z
dc.date.issued2010
dc.description.abstractRationale and Objectives: Pulmonary vascular alteration is one of the characteristic features of chronic obstructive pulmonary disease (COPD). Recent studies suggest that vascular alteration is closely related to endothelial dysfunction and may be further influenced by emphysema. However, the relationship between morphological alteration of small pulmonary vessels and the extent of emphysema has not been assessed in vivo. The objectives of this study are: to evaluate the correlation of total cross-sectional area (CSA) of small pulmonary vessels with the extent of emphysema and airflow obstruction using CT scans and to assess the difference of total CSA between COPD phenotypes.
dc.description.abstractMaterials and Methods: We measured CSA less than 5 mm(2) and 5-10 mm(2), and calculated the percentage of the total CSA for the lung area (%CSA < 5, and %CSA5-10, respectively) using CT scans in 191 subjects. The extent of emphysema (%LAA-950) was calculated, and the correlations of %CSA < 5 and %CSA5-10 with %LAA-950 and results of pulmonary function tests (PFTs) were evaluated. The differences in %CSA between COPD phenotypes were also assessed.
dc.description.abstractResults: The %CSA < 5 had significant negative correlations with %LAA-950 (r = -0.83, P < .0001). There was a weak but statistically significant correlation of %CSA < 5 with forced expiratory volume in 1 second (FEV1)% predicted (r = 0.29, P<.0001) and FEV1/forced vital capacity (r=0.45, P<.0001). A %CSA 5-10 had weak correlations with %LAA-950 and results of PFTs. %CSA < 5 was significantly higher in bronchitis phenotype than in the emphysema phenotype (P<.0001).
dc.description.abstractConclusions: Total CSA of small pulmonary vessels at sub-subsegmental levels strongly correlates with the extent of emphysema (%LAA-950) and reflects differences between COPD phenotypes.
dc.description.funderk23 NIH
dc.description.funderParker B. Francis Foundation
dc.description.funderNATIONAL HEART, LUNG, AND BLOOD INSTITUTE
dc.fechaingreso.objetodigital2024-03-18
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.acra.2009.07.022
dc.identifier.issn1076-6332
dc.identifier.pubmedidMEDLINE:19796970
dc.identifier.urihttps://doi.org/10.1016/j.acra.2009.07.022
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78624
dc.identifier.wosidWOS:000273314500014
dc.information.autorucMedicina;Díaz A;S/I;104496
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final99
dc.pagina.inicio93
dc.publisherELSEVIER SCIENCE INC
dc.revistaACADEMIC RADIOLOGY
dc.rightsacceso restringido
dc.subjectPulmonary disease
dc.subjectchronic obstructive
dc.subjectemphysema
dc.subjectendothelial dysfunction
dc.subjectcomputed tomography
dc.subjectENDOTHELIAL GROWTH-FACTOR
dc.subjectLUNG-DISEASE
dc.subjectARTERIAL STIFFNESS
dc.subjectCELL APOPTOSIS
dc.subjectMILD COPD
dc.subjectSEVERITY
dc.subjectSMOKERS
dc.subjectIDENTIFICATION
dc.subjectHYPERTENSION
dc.subjectVASCULATURE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleQuantitative CT Measurement of Cross-sectional Area of Small Pulmonary Vessel in COPD: Correlations with Emphysema and Airflow Limitation
dc.typeartículo
dc.volumen17
sipa.codpersvinculados104496
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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