Large cation-selective pores from rat liver peroxisomal membranes incorporated to planar lipid bilayers

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dc.contributor.authorLabarca, Pedro
dc.contributor.authorWolff, Daniel
dc.contributor.authorSoto, Ubaldo
dc.contributor.authorNecochea, Cecilia
dc.contributor.authorLeighton, Federico
dc.date.accessioned2019-12-28T02:45:29Z
dc.date.available2019-12-28T02:45:29Z
dc.date.issued1986
dc.description.abstractFusion of a highly purified fraction of rat liver peroxisomal membranes to planar lipid bilayers incorporates large, cation-selective voltage-dependent pores. ThePK/PCl ratio of these pores, estimated in KCl gradients, is close to 4. The pores display several conductance states and spend most of the time open at voltages near 0 mV, closing at more positive and negative voltages. At voltages near 0 mV the most frequent open state has a conductance of 2.4 nS in 0.3m KCl. At voltages more positive and more negative than 10 mV the most frequent open state displays a conductance of 1.2 nS in 0.3m KCl. With these results pore diameters of 3 and 1.5 nm, respectively, can be estimated. We suggest that these pores might account for the unusually high permeability of peroxisomes to low molecular weight solutes. Fusion also incorporates a perfectly anion-selective, two-open states channel with conductances of 50 and 100 pS in 0.1m KCl.
dc.fuente.origenSpringer
dc.identifier.doi10.1007/BF01869724
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/27129
dc.identifier.urihttp://link.springer.com/article/10.1007/BF01869724
dc.identifier.urihttps://doi.org/10.1007/BF01869724
dc.issue.numeroNo. 3
dc.revistaThe Journal of Membrane Biologyes_ES
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.subject.otherPeroxisomases_ES
dc.subject.otherMembranas (Biología)es_ES
dc.titleLarge cation-selective pores from rat liver peroxisomal membranes incorporated to planar lipid bilayerses_ES
dc.typeartículo
dc.volumenVol. 94
sipa.codpersvinculados103446
sipa.codpersvinculados55631
sipa.codpersvinculados98261
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