Inter-hemispheric asymmetry of nigrostriatal dopaminergic lesion: A possible compensatory mechanism in Parkinson's disease

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dc.contributor.authorBlesa, J.
dc.contributor.authorJuri Clavería, Carlos Andrés
dc.contributor.authorGarcia-Cabezas, M. Á.
dc.contributor.authorAdánez, R.
dc.contributor.authorSánchez-González, M. Á.
dc.contributor.authorCavada, C.
dc.contributor.authorObeso, J. A.
dc.date.accessioned2020-01-12T03:37:27Z
dc.date.available2020-01-12T03:37:27Z
dc.date.issued2011
dc.description.abstractThe onset of Parkinson’s disease (PD) is characterized by focal motor features in one body part, which are usually correlated with greater dopaminergic depletion in the contralateral posterior putamen. The role of dopamine (DA) hemispheric differences in the onset and progression of motor symptoms of PD, however, remains undefined. Previous studies have demonstrated that unilateral manipulations of one nigrostriatal system affect contralateral DA turnover, indicating a functional and compensatory inter-dependence of the two nigrostriatal systems. In preliminary data obtained by our group from asymmetric PD patients, a higher asymmetry index as measured by 6-[18F]fluoro-L-dopa (18 F-DOPA) positron emission tomography (PET) was associated with a higher threshold (i.e., greater dopaminergic loss) for the onset of motor symptoms in the less-affected side. To further elucidate the underlying basis for this, we carried out a complementary study in monkeys using PET to assess and correlate the degree of dopaminergic striatal depletion with motor activity. Control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated monkeys with symmetrical lesions were characterized behaviorally and with 18F-DOPA PET. In parallel, an acute lesion was inflicted in the nigrostriatal projection unilaterally in one monkey, generating a 30% dopaminergic depletion in the ipsilateral striatum, which was not associated with any noticeable parkinsonian feature or deficit. The monkey remained asymptomatic for several months. Subsequently, this monkey received systemic MPTP, following which motor behavior and PET were repeatedly evaluated during progression of parkinsonian signs. The brains of all monkeys were processed using immunohistochemical methods. Our results suggest that the onset of motor signs is related to and influenced by the dopaminergic status of the less-affected, contralateral striatum. Although this work is still preliminary, the study agrees with our general hypothesis of hemispheric inter-dependence in the compensation of striatal DA deficit in PD.
dc.fuente.origenFacultad de Medicina
dc.identifier.doi10.3389/fnsys.2011.00092
dc.identifier.issn1662-5137
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/27368
dc.revistaFrontiers in Systems Neurosciencees_ES
dc.rightsacceso abierto
dc.subject18F-DOPAes_ES
dc.subjectCompensatory mechanismses_ES
dc.subjectDopaminergices_ES
dc.subjectMPTPes_ES
dc.subjectParkinson's diseasees_ES
dc.subjectPETes_ES
dc.subject1,2,3,6 tetrahydro 1 methyl 4 phenylpyridinees_ES
dc.subject6 fluorodopa f 18es_ES
dc.subjectTyrosine 3 monooxygenasees_ES
dc.subjectAnimal experimentes_ES
dc.subjectAnimal modeles_ES
dc.subjectAnimal tissuees_ES
dc.subjectArticlees_ES
dc.subjectBrain asymmetryes_ES
dc.subjectControlled studyes_ES
dc.subjectCorpus striatumes_ES
dc.subjectDopaminergic nerve celles_ES
dc.subjectDopaminergic systemes_ES
dc.subjectHaplorhinies_ES
dc.subjectImmunohistochemistryes_ES
dc.subjectLocomotiones_ES
dc.subjectMesencephalones_ES
dc.subjectMotor activityes_ES
dc.subjectNeuroimaginges_ES
dc.subjectNigroneostriatal systemes_ES
dc.subjectNonhumanes_ES
dc.subjectParkinson diseasees_ES
dc.subjectPositron emission tomographyes_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleInter-hemispheric asymmetry of nigrostriatal dopaminergic lesion: A possible compensatory mechanism in Parkinson's diseasees_ES
dc.typeartículo
sipa.codpersvinculados7476
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