Molecular differentiation of high- and moderate-grade human prostate cancer by cDNA microarray analysis

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dc.contributor.authorBest, CJM
dc.contributor.authorLeiva, IM
dc.contributor.authorChuaqui, RF
dc.contributor.authorGillespie, JW
dc.contributor.authorDuray, PH
dc.contributor.authorMurgai, M
dc.contributor.authorZhao, YD
dc.contributor.authorSimon, R
dc.contributor.authorKang, JJ
dc.contributor.authorGreen, JE
dc.contributor.authorBostwick, DG
dc.contributor.authorLinehan, WM
dc.contributor.authorEmmert Buck, MR
dc.date.accessioned2024-01-10T13:15:06Z
dc.date.available2024-01-10T13:15:06Z
dc.date.issued2003
dc.description.abstractThe prognosis of men with moderate-grade prostate cancer is uncertain. At present, there are few if any reliable molecular markers that can distinguish moderate-grade tumors from those that behave more aggressively. To better understand the molecular basis of human prostate cancer and potentially provide information toward more accurate prognosis, we measured and analyzed gene expression profiles of 13 high- and moderate-grade human prostate tumors using cDNA microarrays. The expression of 136 genes was observed to differ significantly (P < 0.001) between normal prostate and tumors using one-sample t testing and Wilcoxon ranking. Hierarchical clustering of genes demonstrated a relatively similar pattern of differential expression across the tumors. However, importantly, permutation t tests (two-tailed P < 0.001) revealed 21 genes whose expression profiles segregated moderate- and high-grade tumors from each other, which was significantly (P < 0.03) Greater than what was expected by chance. These results were compared in silico with prostate cancer profiling efforts performed by other groups, including a meta-analysis of four data sets. which validated many of the dysregulated genes. We suggest that these data provide insight into the molecular nature of clinically aggressive prostate cancer.
dc.description.funderDIVISION OF BASIC SCIENCES - NCI
dc.description.funderDIVISION OF CLINICAL SCIENCES - NCI
dc.description.funderNATIONAL CANCER INSTITUTE
dc.fechaingreso.objetodigital2024-05-02
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/00019606-200306000-00001
dc.identifier.eissn1533-4066
dc.identifier.issn1052-9551
dc.identifier.pubmedidMEDLINE:12766610
dc.identifier.urihttps://doi.org/10.1097/00019606-200306000-00001
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78471
dc.identifier.wosidWOS:000183087800001
dc.information.autorucMedicina;Leiva I;S/I;75938
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final70
dc.pagina.inicio63
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaDIAGNOSTIC MOLECULAR PATHOLOGY
dc.rightsacceso restringido
dc.subjectaggressive prostate cancer
dc.subjectgene expression profiling
dc.subjectcDNA microarrays
dc.subjectGENE-EXPRESSION PROFILES
dc.subjectCELL-ADHESION MOLECULE
dc.subjectALPHA-1-ACID GLYCOPROTEIN
dc.subjectCOMPLEMENTARY-DNA
dc.subjectBENIGN
dc.subjectADENOCARCINOMA
dc.subjectPROGRESSION
dc.subjectHYPERPLASIA
dc.subjectALCAM
dc.subjectOVEREXPRESSION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMolecular differentiation of high- and moderate-grade human prostate cancer by cDNA microarray analysis
dc.typeartículo
dc.volumen12
sipa.codpersvinculados75938
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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