Studies on quinones. Part 39: Synthesis and leishmanicidal activity of acylchloroquinones and hydroquinones

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dc.contributor.authorValderrama, JA
dc.contributor.authorZamorano, C
dc.contributor.authorGonzalez, MF
dc.contributor.authorPrina, E
dc.contributor.authorFournet, A
dc.date.accessioned2024-01-10T14:21:45Z
dc.date.available2024-01-10T14:21:45Z
dc.date.issued2005
dc.description.abstractAcylhydroquinone-based compounds are attractive targets for the design of new leishmanicidal drugs. We have previously described sesquiterpene quinones and hydroquinones series, which exhibit different degree of potency against Leishmania amazonensis. The present study details the preparation of acylchloroquinones and hydroquinones possessing lipophilic substituents and examines their in vitro activity against intracellular L. amazonensis amastigotes. The quinone or hydroquinone nucleus is essential for the activity of the members of the series. The lipophilicity of the cycloaliphatic systems in these members seems to attenuate the cytotoxical effect and increases the selectivity of those compounds containing the norbornene system. (c) 2005 Elsevier Ltd. All rights reserved.
dc.fechaingreso.objetodigital20-03-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.bmc.2005.04.041
dc.identifier.eissn1464-3391
dc.identifier.issn0968-0896
dc.identifier.pubmedidMEDLINE:15876538
dc.identifier.urihttps://doi.org/10.1016/j.bmc.2005.04.041
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79772
dc.identifier.wosidWOS:000229811900002
dc.information.autorucQuímica;Valderrama J;S/I;98772
dc.issue.numero13
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final4159
dc.pagina.inicio4153
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.revistaBIOORGANIC & MEDICINAL CHEMISTRY
dc.rightsacceso restringido
dc.subjectANTIPROTOZOAL ACTIVITY
dc.subjectHEXADECYLPHOSPHOCHOLINE
dc.subject1,4-BENZOQUINONES
dc.subjectCHEMOTHERAPY
dc.subjectCHEMISTRY
dc.subjectAMBISOME
dc.subjectACCESS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleStudies on quinones. Part 39: Synthesis and leishmanicidal activity of acylchloroquinones and hydroquinones
dc.typeartículo
dc.volumen13
sipa.codpersvinculados98772
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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