Asymptomatic Herpes Simplex Virus Type 1 Infection Causes an Earlier Onset and More Severe Experimental Autoimmune Encephalomyelitis

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dc.article.number635257
dc.catalogadorpva
dc.contributor.authorDuarte Peñaloza, Luisa Fernanda
dc.contributor.authorAltamirano Lagos, María J.
dc.contributor.authorTabares Guevara, Jorge H.
dc.contributor.authorOpazo, María Cecilia
dc.contributor.authorDíaz, Máximo
dc.contributor.authorNavarrete, Romina
dc.contributor.authorMuza, Catalina
dc.contributor.authorVallejos Galvez, Omar Patricio
dc.contributor.authorRiedel Soria, Claudia
dc.contributor.authorBueno Ramírez, Susan
dc.contributor.authorKalergis Parra, Alexis Mikes
dc.contributor.authorGonzález Muñoz, Pablo Alberto
dc.date.accessioned2024-01-23T19:16:53Z
dc.date.available2024-01-23T19:16:53Z
dc.date.issued2021
dc.description.abstractMultiple sclerosis (MS) is an increasingly prevalent progressive autoimmune and debilitating chronic disease that involves the detrimental recognition of central nervous system (CNS) antigens by the immune system. Although significant progress has been made in the last decades on the biology of MS and the identification of novel therapies to treat its symptoms, the etiology of this disease remains unknown. However, recent studies have suggested that viral infections may contribute to disease onset. Interestingly, a potential association between herpes simplex virus type 1 (HSV-1) infection and MS has been reported, yet a direct relationship among both has not been conclusively demonstrated. Experimental autoimmune encephalomyelitis (EAE) recapitulates several aspects of MS in humans and is widely used to study this disease. Here, we evaluated the effect of asymptomatic brain infection by HSV-1 on the onset and severity of EAE in C57BL/6 mice. We also evaluated the effect of infection with an HSV-1-mutant that is attenuated in neurovirulence and does not cause encephalitis. Importantly, we observed more severe EAE in mice previously infected either, with the wild-type (WT) or the mutant HSV-1, as compared to uninfected control mice. Also, earlier EAE onset was seen after WT virus inoculation. These findings support the notion that a previous exposure to HSV-1 can accelerate and enhance EAE, which suggests a potential contribution of asymptomatic HSV-1 to the onset and severity of MS.
dc.fechaingreso.objetodigital2024-01-23
dc.fuente.origenConveris
dc.identifier.converisid1
dc.identifier.doi10.3389/fimmu.2021.635257
dc.identifier.issn1664-3224
dc.identifier.pubmedidMEDLINE:33679788
dc.identifier.scopusid000623032600001
dc.identifier.urihttps://doi.org/10.3389/fimmu.2021.635257
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80923
dc.identifier.wosidWOS:000623032600001
dc.information.autorucFacultad de Ciencias Biológicas; Duarte Peñaloza, Luisa Fernanda; 0000-0003-1828-1800; 1031205
dc.information.autorucFacultad de Ciencias Biológicas; Vallejos Galvez, Omar Patricio; S/I; 215421
dc.information.autorucFacultad de Ciencias Biológicas; Riedel Soria, Claudia; S/I; 88772
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan; 0000-0002-7551-8088; 113541
dc.information.autorucFacultad de Ciencias Biológicas; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.information.autorucFacultad de Ciencias Biológicas; González Muñoz, Pablo Alberto; 0000-0001-7709-6870; 15616
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final17
dc.pagina.inicio1
dc.revistaFrontiers in Immunologyes_ES
dc.rightsacceso abierto
dc.rights.licenseCreative Commons Attribution License (CC BY)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHSV-1es_ES
dc.subjectViral infectiones_ES
dc.subjectMultiple sclerosises_ES
dc.subjectExperimental autoimmune encephalomyelitises_ES
dc.subjectNeuroinflammationes_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAsymptomatic Herpes Simplex Virus Type 1 Infection Causes an Earlier Onset and More Severe Experimental Autoimmune Encephalomyelitises_ES
dc.typeartículo
dc.volumen12
sipa.codpersvinculados1031205
sipa.codpersvinculados215421
sipa.codpersvinculados88772
sipa.codpersvinculados113541
sipa.codpersvinculados90610
sipa.codpersvinculados15616
sipa.trazabilidadConveris;20-07-2021
sipa.trazabilidadORCID;2024-01-15
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