Protective Role of the ACE2/Ang-(1-9) Axis in Cardiovascular Remodeling

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dc.article.number594361
dc.catalogadorvzp
dc.contributor.authorJalil Milad, Jorge Emilio
dc.contributor.authorOcaranza Jeraldino, María Paz
dc.date.accessioned2024-06-04T18:57:03Z
dc.date.available2024-06-04T18:57:03Z
dc.date.issued2012
dc.description.abstractDespite reduction in cardiovascular (CV) events and end-organ damage with the current pharmacologic strategies, CV disease remains the primary cause of death in the world. Pharmacological therapies based on the renin angiotensin system (RAS) blockade are used extensively for the treatment of hypertension, heart failure, and CV remodeling but in spite of their success the prevalence of end-organ damage and residual risk remain still high. Novel approaches must be discovered for a more effective treatment of residual CV remodeling and risk. The ACE2/Ang-(1–9) axis is a new and important target to counterbalance the vasoconstrictive/proliferative RAS axis. Ang-(1–9) is hydrolyzed slower than Ang-(1–7) and is able to bind the Ang II type 2 receptor. We review here the current experimental evidence suggesting that activation of the ACE2/Ang-(1–9) axis protects the heart and vessels (and possibly the kidney) from adverse cardiovascular remodeling in hypertension as well as in heart failure.
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2024-06-04
dc.format.extent12 páginas
dc.fuente.origenHistorial Académico
dc.identifier.citationOcaranza M, Jalil J. Protective Role of the ACE2/Ang-(1-9) Axis in Cardiovascular Remodeling. International Journal Of Hypertension. 2012;2012:Art. 594361-594373.
dc.identifier.urihttp://www.hindawi.com/journals/ijht/2012/594361/
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86402
dc.information.autorucEscuela de Medicina; Jalil Milad, Jorge Emilio; 0000-0001-6877-2072; 99946
dc.information.autorucEscuela de Medicina; Ocaranza Jeraldino, María Paz; 0000-0002-4915-6378; 1001254
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final594373
dc.pagina.final12
dc.pagina.inicio1
dc.revistaInternational journal of hypertension
dc.rightsacceso abierto
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddc610
dc.subject.deweyMedicina y salud
dc.titleProtective Role of the ACE2/Ang-(1-9) Axis in Cardiovascular Remodeling
dc.typeartículo de revisión
dc.volumen2012
sipa.codpersvinculados99946
sipa.codpersvinculados1001254
sipa.trazabilidadHistorial Académico;09-07-2021
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