Simultaneous Highly Efficient Contrast-Free Lumen and Vessel Wall MR Imaging for Anatomical Assessment of Aortic Disease

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dc.catalogadorgjm
dc.contributor.authorMuñoz, Camila
dc.contributor.authorFotaki, Anastasia
dc.contributor.authorHua, Alina
dc.contributor.authorHajhosseiny, Reza
dc.contributor.authorKunze, Karl P.
dc.contributor.authorIsmail, Tevfik F.
dc.contributor.authorNeji, Radhouene
dc.contributor.authorPushparajah, Kuberan
dc.contributor.authorBotnar, René Michael
dc.contributor.authorPrieto Vásquez, Claudia
dc.date.accessioned2024-01-30T15:23:31Z
dc.date.available2024-01-30T15:23:31Z
dc.date.issued2023
dc.description.abstractBackground: Bright-blood lumen and black-blood vessel wall imaging are required for the comprehensive assessment of aortic disease. These images are usually acquired separately, resulting in long examinations and potential misregistration between images. Purpose: To characterize the performance of an accelerated and respiratory motion-compensated three-dimensional (3D) cardiac MRI technique for simultaneous contrast-free aortic lumen and vessel wall imaging with an interleaved T2 and inversion recovery prepared sequence (iT2Prep-BOOST). Study Type: Prospective. Population: A total of 30 consecutive patients with aortopathy referred for a clinically indicated cardiac MRI examination (9 females, mean age ± standard deviation: 32 ± 12 years). Field Strength/Sequence: 1.5-T; bright-blood MR angiography (diaphragmatic navigator-gated T2-prepared 3D balanced steady-state free precession [bSSFP], T2Prep-bSSFP), breath-held black-blood two-dimensional (2D) half acquisition single-shot turbo spin echo (HASTE), and 3D bSSFP iT2Prep-BOOST. Assessment: iT2Prep-BOOST bright-blood images were compared to T2prep-bSSFP images in terms of aortic vessel dimensions, lumen-to-myocardium contrast ratio (CR), and image quality (diagnostic confidence, vessel sharpness and presence of artifacts, assessed by three cardiologists on a 4-point scale, 1: nondiagnostic to 4: excellent). The iT2Prep-BOOST black-blood images were compared to 2D HASTE images for quantification of wall thickness. A visual comparison between computed tomography (CT) and iT2Prep-BOOST was performed in a patient with chronic aortic dissection. Statistical Tests: Paired t-tests, Wilcoxon signed-rank tests, intraclass correlation coefficient (ICC), Bland–Altman analysis. A P value < 0.05 was considered statistically significant. Results: Bright-blood iT2Prep-BOOST resulted in significantly improved image quality (mean ± standard deviation 3.8 ± 0.5 vs. 3.3 ± 0.8) and CR (2.9 ± 0.8 vs. 1.8 ± 0.5) compared with T2Prep-bSSFP, with a shorter scan time (7.8 ± 1.7 minutes vs. 12.9 ± 3.4 minutes) while providing a complementary 3D black-blood image. Aortic lumen diameter and vessel wall thickness measurements in bright-blood and black-blood images were in good agreement with T2Prep-bSSFP and HASTE images (<0.02 cm and <0.005 cm bias, respectively) and good intrareader (ICC > 0.96) and interreader (ICC > 0.94) agreement was observed for all measurements. Data Conclusion: iT2Prep-BOOST might enable time-efficient simultaneous bright- and black-blood aortic imaging, with improved image quality compared to T2Prep-bSSFP and HASTE imaging, and comparable measurements for aortic wall and lumen dimensions. Evidence Level: 2. Technical Efficacy: Stage 2.
dc.fechaingreso.objetodigital2024-06-05
dc.fuente.origenORCID
dc.identifier.doi10.1002/jmri.28613
dc.identifier.urihttps://kclpure.kcl.ac.uk/portal/en/publications/11fac10f-169d-448a-9ceb-dddedf2d0767
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81069
dc.information.autorucEscuela de Ingeniería; Botnar, René Michael; 0000-0002-9447-4367; 1015313
dc.information.autorucEscuela de Ingeniería; Prieto Vásquez, Claudia; 0000-0003-4602-2523; 14195
dc.language.isoen
dc.nota.accesoContenido completo
dc.rightsacceso abierto
dc.subject.ddc600
dc.subject.deweyTecnologíaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSimultaneous Highly Efficient Contrast-Free Lumen and Vessel Wall MR Imaging for Anatomical Assessment of Aortic Disease
dc.typeartículo
sipa.codpersvinculados1015313
sipa.codpersvinculados14195
sipa.trazabilidadORCID;2024-01-15
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