Antibodies against galectin-8 in patients with systemic lupus erythematosus

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dc.contributor.authorPardo, E
dc.contributor.authorCarcamo, C
dc.contributor.authorMassardo, L
dc.contributor.authorMezzano, V
dc.contributor.authorJacobelli, S
dc.contributor.authorGonzalez, A
dc.contributor.authorSoza, A
dc.date.accessioned2024-01-10T13:11:08Z
dc.date.available2024-01-10T13:11:08Z
dc.date.issued2006
dc.description.abstractBackground: The family of lectins known as galectins (galectins 1-14) are involved in the regulation of the immune system and in oncogenesis. During a search for antigens recognized by antibodies produced by a patient with systemic lupus erythematosus described. Aim: To determine the frequency of autoantibodies against galectin-8 in lupus patients compared with healthy controls. Patients and Methods: Galectin-8 was purified from a bacterial expression system and used in immunoblot assays as antigen to screen the sera of 55 SLE patients and matched controls. Disease activity was evaluated using the Mexican Modification of the Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI). Results: Reactivity against galectin-8 was detected in 30% of SLE patients, compared to 7% ofcontrols (p = 0.003). We could not detect any particular SLE manifestation associated to the pressence of these autoantibodies. Conclusion: This is the first description of autoantibodies against galectin-8. Its higher frequency in a patients with SLE suggests a pathogenic role. Further studies are needed to determine their clinical relevance (Rev Med Chile 2006; 134: 159-66).
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:16554922
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78002
dc.identifier.wosidWOS:000236694100004
dc.information.autorucMedicina;Carcamo C;S/I;562
dc.information.autorucMedicina;Gonzalez A;S/I;52306
dc.information.autorucMedicina;Jacobelli S;S/I;98345
dc.information.autorucMedicina;Massardo L;S/I;100068
dc.information.autorucMedicina;Mezzano V;S/I;1622
dc.information.autorucCiencias Biológicas;Pardo E;S/I;13491
dc.information.autorucMedicina;Soza A;S/I;129570
dc.issue.numero2
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final166
dc.pagina.inicio159
dc.publisherSOC MEDICA SANTIAGO
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsregistro bibliográfico
dc.subjectautoantibodies
dc.subjectgalectin 8
dc.subjectlupus erythematosus
dc.subjectsystemic
dc.subjectRIBOSOMAL-P-AUTOANTIBODIES
dc.subjectCELL-ADHESION
dc.subjectANTI-GALECTIN-1 AUTOANTIBODIES
dc.subjectIGG AUTOANTIBODIES
dc.subjectBINDING-PROTEIN
dc.subjectLIVING CELLS
dc.subjectT-CELLS
dc.subjectAPOPTOSIS
dc.subjectDISEASE
dc.subjectINTEGRINS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAntibodies against galectin-8 in patients with systemic lupus erythematosus
dc.typeartículo
dc.volumen134
sipa.codpersvinculados562
sipa.codpersvinculados52306
sipa.codpersvinculados98345
sipa.codpersvinculados100068
sipa.codpersvinculados1622
sipa.codpersvinculados13491
sipa.codpersvinculados129570
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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