Acute Cerebrovascular events associated to hemolytic uremic syndrome: Description of two pediatric cases

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dc.catalogadorcrc
dc.contributor.authorLopez, M.
dc.contributor.authorHuete, Isidro
dc.contributor.authorHernández Chávez, Marta Isabel
dc.date.accessioned2023-04-04T17:14:46Z
dc.date.available2023-04-04T17:14:46Z
dc.date.issued2017
dc.description.abstractIntroduction: Diarrhea-associated Hemolytic Uremic Syndrome (D+HUS) is a multisystem disorder in which neurological involvement (35 to 50%) is associated to adverse outcome. An important cause of a permanent neurological impairment is the cerebrovascular pathology. Objective: To report two pediatric cases of D+HUS with severe neurological involvement due to cerebrovascular disease, and review available literature. Clinical cases: Two previously healthy 15- and 21-month-old children debuted with seizures and impairment of consciousness within the first week of a D+HUS. Both presented hypertension, severe acute renal failure, and focal motor deficit. One child showed significant improvement in neurologic status after five sessions of plasmapheresis. Brain magnetic resonance showed in the first child multiple bilateral infarcts of small vessels and lesions of white matter. In the second patient, large bilateral infarcts on both middle cerebral arteries territories were identified. One year after the acute event, both children showed functional impairment; The first patient evolved with language delay and spastic hemiparesis; the second patient with spastic quadriparesis, epilepsy with poor seizure control and marked functional impairment. Conclusion: Although most of the children with D+HUS and brain involvement do not have long-term sequelae, cerebrovascular disease in the acute period causes permanent damage, and in addition to the management of electrolyte disturbances, hypertension, and renal failure, therapies directed at specific pathophysiological mechanisms that trigger vascular compromise may improve prognosis.
dc.fechaingreso.objetodigital2023-04-04
dc.format.extent7 páginas
dc.fuente.origenSIPA
dc.identifier.citationLópez, M, Huete, I, & Hernández, Marta. (2017). Acute Cerebrovascular events associated to hemolytic uremic syndrome: Description of two pediatric cases. Revista chilena de pediatría, 88(5), 640-646. https://dx.doi.org/10.4067/S0370-41062017000500011
dc.identifier.doi10.4067/S0370-41062017000500011
dc.identifier.issn0370-4106
dc.identifier.pubmedidMEDLINE:29546950
dc.identifier.scopusidSCOPUS_ID:85035798559
dc.identifier.urihttps://doi.org/10.4067/S0370-41062017000500011
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/66718
dc.identifier.wosidWOS:000416507900011
dc.information.autorucEscuela de medicina;Huete Garín, Isidro Alvaro;0000-0002-8746-1111;731
dc.information.autorucEscuela de medicina;Hernández Chávez Marta Isabel;0000-0002-4238-8969; 55673
dc.issue.numero5
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final646
dc.pagina.inicio640
dc.revistaRevista chilena de pediatría
dc.rightsacceso abierto
dc.subjectThrombotic microangiopathy
dc.subjectAcute renal failure
dc.subjectThrombotic microangiopathy
dc.subjectHemolytic Uremic Syndrome
dc.subject.ddc610
dc.subject.deweyMedicina y salud
dc.titleAcute Cerebrovascular events associated to hemolytic uremic syndrome: Description of two pediatric cases
dc.title.alternativeCompromiso cerebrovascular agudo en síndrome hemolítico urémico: descripción de dos casos pediátricos
dc.typeartículo
dc.volumen88
sipa.codpersvinculados731
sipa.codpersvinculados55673
sipa.indexScopus
sipa.indexPubmed
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