M-protein gene-type distribution and hyaluronic acid capsule in group A Streptococcus clinical isolates in Chile: association of emm gene markers with csrR alleles

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dc.contributor.authorWozniak, A.
dc.contributor.authorRojas, P.
dc.contributor.authorRodriguez, C.
dc.contributor.authorUndabarrena, A.
dc.contributor.authorGarate, C.
dc.contributor.authorRiedel, I.
dc.contributor.authorRoman, J. C.
dc.contributor.authorKalergis, A. M.
dc.contributor.authorGarcia, P.
dc.date.accessioned2024-01-10T12:06:47Z
dc.date.available2024-01-10T12:06:47Z
dc.date.issued2012
dc.description.abstractStreptococcus pyogenes causes a variety of infections because of virulence factors such as capsular hyaluronic acid and M protein. The aim of this study was to determine emm types and capsule phenotype in 110 isolates of S. pyogenes from patients with invasive (sterile sites) and non-invasive (mainly pharyngitis) infections in Chile, and the relationship between both virulence factors. The most abundant types found were emm12, emm1, emm4 and emm28 and their distribution was similar to that seen in Latin America and developed countries, but very different from that in Asia and Pacific Island countries. Ten of 16 emm types identified in pharyngeal isolates were found in sterile-site isolates, and three of nine emm types of sterile-site isolates occurred in pharyngeal isolates; three emm subtypes were novel. The amount of hyaluronic acid was significantly higher in sterile-site isolates but did not differ substantially among emm types. Only three isolates were markedly capsulate and two of them had mutations in the csrR gene that codes for a repressor of capsule synthesis genes. We found a non-random association between emm types and csrR gene alleles suggesting that horizontal gene transfer is not freely occurring in the population.
dc.description.funderDepartment of Clinical Laboratories at Pontificia Universidad Catolica de Chile
dc.description.funderSentry Programme
dc.description.funderMillennium Nucleus of Immunology and Immunotheraphy
dc.fechaingreso.objetodigital2024-04-25
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1017/S0950268811001889
dc.identifier.issn0950-2688
dc.identifier.pubmedidMEDLINE:21906413
dc.identifier.urihttps://doi.org/10.1017/S0950268811001889
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76206
dc.identifier.wosidWOS:000304013100014
dc.information.autorucMedicina;Garate C ;S/I;1006778
dc.information.autorucMedicina;Garcia P ;S/I;73909
dc.information.autorucCiencias Biológicas;Kalergis A;S/I;90610
dc.information.autorucMedicina;Riedel I;S/I;115614
dc.information.autorucMedicina;Roman J;S/I;117336
dc.information.autorucMedicina;Undabarrena A ;S/I;163485
dc.information.autorucMedicina;Wozniak A ;S/I;1008612
dc.issue.numero7
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1295
dc.pagina.inicio1286
dc.publisherCAMBRIDGE UNIV PRESS
dc.revistaEPIDEMIOLOGY AND INFECTION
dc.rightsacceso restringido
dc.subjectAntibiotic resistance
dc.subjectmolecular epidemiology
dc.subjectStreptococcus pyogenes
dc.subjectRESISTANT STAPHYLOCOCCUS-AUREUS
dc.subject2-COMPONENT REGULATORY SYSTEM
dc.subjectVIRULENCE FACTORS
dc.subjectUNITED-STATES
dc.subjectANTIBIOTIC-RESISTANCE
dc.subjectKLEBSIELLA-PNEUMONIAE
dc.subjectRHEUMATIC-FEVER
dc.subjectSOUTH-AMERICA
dc.subjectPYOGENES
dc.subjectINFECTIONS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleM-protein gene-type distribution and hyaluronic acid capsule in group A Streptococcus clinical isolates in Chile: association of emm gene markers with csrR alleles
dc.typeartículo
dc.volumen140
sipa.codpersvinculados1006778
sipa.codpersvinculados73909
sipa.codpersvinculados90610
sipa.codpersvinculados115614
sipa.codpersvinculados117336
sipa.codpersvinculados163485
sipa.codpersvinculados1008612
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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