Rising infant mortality in down syndrome in Chile from 1997 to 2013

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dc.contributor.authorDonoso, Enrique
dc.contributor.authorVera, Claudio
dc.date.accessioned2024-01-10T14:21:35Z
dc.date.available2024-01-10T14:21:35Z
dc.date.issued2016
dc.description.abstractBackground: Down syndrome (DS) is associated with higher child mortality especially due to cardiac malformations. Aim: To describe the trend in Chilean infant mortality in DS in the period 1997-2013 as compared to the general population without DS. Material and Methods: Raw data on infant deaths were extracted from the yearbooks of vital statistics of the National Institute of Statistics. The mortality risk associated to DS, relative to population without DS was estimated. Results: There were 456 deaths in infants with DS during the study period (59 early neonatal deaths, 70 late neonatal deaths and 327 post-neonatal deaths). The trend in infant mortality rate in DS was ascending (r: 0.53, p = 0.03), with an average annual percentage change of 4.6% (95% confidence interval (CI) 0.4-9.0%; p < 0.01). Compared to the population without DS, the risk of early neonatal death was lower in DS (Odds ratio (OR) 0.14, 95% CI 0.11-0.19; p < 0.01) whereas the risk of post-neonatal death was higher (OR 4.74, 95% CI 3.85-5.85; p < 0.01). Conclusions: Infant mortality in Down syndrome has an increasing trend. We postulate that these children are not accessing timely cardiac surgery, the main therapeutic tool to reduce the death risk in the first year of life.
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:28394960
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79716
dc.identifier.wosidWOS:000390353000009
dc.information.autorucMedicina;Donoso E.;S/I;99155
dc.information.autorucMedicina;Vera C.;S/I;687
dc.issue.numero11
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final1439
dc.pagina.inicio1432
dc.publisherSOC MEDICA SANTIAGO
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsregistro bibliográfico
dc.subjectChile
dc.subjectDown Syndrome
dc.subjectHeart Defects
dc.subjectCongenital
dc.subjectInfant Mortality
dc.subjectCONGENITAL HEART-DISEASE
dc.subjectUNITED-STATES
dc.subjectPRENATAL-DIAGNOSIS
dc.subjectTERMINATION RATES
dc.subjectSURVIVAL
dc.subjectCHILDREN
dc.subjectPREVALENCE
dc.subjectMALFORMATIONS
dc.subjectPOPULATION
dc.subjectADULTS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRising infant mortality in down syndrome in Chile from 1997 to 2013
dc.typeartículo
dc.volumen144
sipa.codpersvinculados99155
sipa.codpersvinculados687
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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