Overexpression of 11 beta-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue and portal hypercortisolism in non-alcoholic fatty liver disease

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dc.contributor.authorCandia, Roberto
dc.contributor.authorRiquelme, Arnoldo
dc.contributor.authorBaudrand, Rene
dc.contributor.authorCarvajal, Cristian A.
dc.contributor.authorMorales, Mauricio
dc.contributor.authorSolis, Nancy
dc.contributor.authorPizarro, Margarita
dc.contributor.authorEscalona, Alex
dc.contributor.authorCarrasco, Gonzalo
dc.contributor.authorBoza, Camilo
dc.contributor.authorPerez, Gustavo
dc.contributor.authorPadilla, Oslando
dc.contributor.authorCerda, Jaime
dc.contributor.authorFardella, Carlos E.
dc.contributor.authorArrese, Marco
dc.date.accessioned2024-01-10T13:16:01Z
dc.date.available2024-01-10T13:16:01Z
dc.date.issued2012
dc.description.abstractBackground: The enzyme 11 beta-hydroxysteroid-dehydrogenase type 1 (11 beta HSD1) catalyses the reactivation of intracellular cortisol. We explored the potential role of 11 beta-HSD1 overexpression in visceral adipose tissue (VAT) in non-alcoholic fatty liver disease (NAFLD) assessing sequential changes of enzyme expression, in hepatic and adipose tissue, and the occurrence of portal hypercortisolism in obese mice. 11 beta-HSD1 expression was also assessed in tissues from obese patients undergoing bariatric surgery. Methods: Peripheral and portal corticosterone levels and liver histology were assessed in ob/ob mice at two time points (8-12 weeks of age). 11 beta-HSD1 tissue expression was assessed in by RT-pcr in ob/ob mice and in 49 morbidly obese patients. Results: Portal corticosterone serum levels were higher in obese mice with a 26% decrease between 8 and 12 weeks of age (controls: 78.3 +/- 19.7 ng/ml, 8-week-old ob/ob: 167.5 +/- 14.5 ng/ml and 12-week-old ob/ob: 124.3 +/- 28 ng/ml, P < 0.05). No significant differences were found in peripheral corticosterone serum levels. Expression of 11b-HSD1 was lower in the liver [-45% at 8 weeks and -35% at 12-weeks (P = 0.0001)] and highly overexpressed in VAT in obese mice, compared to controls (128-fold higher in 8-week-old ob/ob and 41-fold higher in 12-week-old ob/ob, P < 0.01). No significant differences were seen in the expression of 11 beta-HSD1 in subcutaneous adipose tissue. In multivariate analysis, human 11 beta-HSD1 expression in VAT (OR: 1.385 +/- 1.010-1.910) was associated with NAFLD. Conclusion: Murine NAFLD is associated with portal hypercortisolism and 11 beta-HSD1 overexpression in VAT. In humans, 11 beta-HSD1 VAT expression was associated with the presence of NAFLD. Thus, local corticosteroid production in VAT may contribute to NAFLD pathogenesis.
dc.description.funderFONDECYT (Fondo Nacional de Ciencia y Tecnologia)
dc.description.funderFONDEF
dc.description.funderMillenium Nucleus in immunology and Immunotherapy
dc.fechaingreso.objetodigital2024-05-14
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/j.1478-3231.2011.02685.x
dc.identifier.eissn1478-3231
dc.identifier.issn1478-3223
dc.identifier.pubmedidMEDLINE:22136330
dc.identifier.urihttps://doi.org/10.1111/j.1478-3231.2011.02685.x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78551
dc.identifier.wosidWOS:000300006500005
dc.information.autorucMedicina;Arrese M ;S/I;76095
dc.information.autorucMedicina;Baudrand R ;S/I;1024
dc.information.autorucMedicina;Boza C;S/I;761
dc.information.autorucMedicina;Candia R ;S/I;16705
dc.information.autorucMedicina;Carvajal C;S/I;8586
dc.information.autorucMedicina;Cerda J ;S/I;3935
dc.information.autorucMedicina;Escalona A;S/I;94025
dc.information.autorucMedicina;Fardella C;S/I;66235
dc.information.autorucMedicina;Morales M;S/I;132634
dc.information.autorucMedicina;Padilla O;S/I;102063
dc.information.autorucMedicina;Perez G;S/I;5510
dc.information.autorucMedicina;Pizarro M ;S/I;102250
dc.information.autorucMedicina;Riquelme A ;S/I;3538
dc.information.autorucMedicina;Solis N ;S/I;102379
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final399
dc.pagina.inicio392
dc.publisherWILEY
dc.revistaLIVER INTERNATIONAL
dc.rightsacceso restringido
dc.subject11beta-HSD1
dc.subjectfatty liver
dc.subjectglucocorticoids
dc.subjectliver steatosis
dc.subjectnon-alcoholic
dc.subjectINSULIN-RESISTANCE
dc.subjectMETABOLIC-SYNDROME
dc.subjectCORTISOL
dc.subjectEXPRESSION
dc.subjectOBESITY
dc.subjectSTEATOHEPATITIS
dc.subjectMANAGEMENT
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleOverexpression of 11 beta-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue and portal hypercortisolism in non-alcoholic fatty liver disease
dc.typeartículo
dc.volumen32
sipa.codpersvinculados76095
sipa.codpersvinculados1024
sipa.codpersvinculados761
sipa.codpersvinculados16705
sipa.codpersvinculados8586
sipa.codpersvinculados3935
sipa.codpersvinculados94025
sipa.codpersvinculados66235
sipa.codpersvinculados132634
sipa.codpersvinculados102063
sipa.codpersvinculados5510
sipa.codpersvinculados102250
sipa.codpersvinculados3538
sipa.codpersvinculados102379
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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