Genetic evidence that apolipoprotein E4 is not a relevant susceptibility factor for cholelithiasis in two high-risk populations

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dc.contributor.authorMella, Juan G.
dc.contributor.authorSchirin Sokhan, Ramin
dc.contributor.authorRigotti, Attilio
dc.contributor.authorPimentel, Fernando
dc.contributor.authorVillarroel, Luis
dc.contributor.authorWasmuth, Hermann E.
dc.contributor.authorSauerbruch, Tilman
dc.contributor.authorNervi, Flavio
dc.contributor.authorLammert, Frank
dc.contributor.authorMiquel, Juan Francisco
dc.date.accessioned2024-01-10T12:05:41Z
dc.date.available2024-01-10T12:05:41Z
dc.date.issued2007
dc.description.abstractApolipoprotein E (apoE) isoforms are genetic determinants of interindividual variations in lipid metabolism. To assess whether apoE is a genetic risk factor for cholesterol gallstone disease (GD), we analyzed apoE variants in populations from Chile and Germany, two countries with very high prevalence rates of this disease. ApoE genotypes were determined in Chilean gallstone patients (n = 117) and control subjects (n = 122) as well as in German gallstone patients ( n 5 184) and matched controls (n = 184). In addition, we studied apoE variants in subgroups of Chilean patients with strong differences in their susceptibility to acquire gallstones: 50 elderly subjects without gallstones in spite of well-known risk factors for this disease (gallstone-resistant) and 32 young individuals with gallstones but without risk factors (gallstone-susceptible). Furthermore, correlation analysis of apoE genotypes with cholesterol crystal formation times, biliary cholesterol saturation index (CSI), and gallstone cholesterol contents was performed in 81 cholecystectomized patients. In this study analyzing the largest sample set available, apoE4 genotype was not associated with an increased frequency of GD in either population. Moreover, in the Chilean population after adjusting for risk factors such as gender, age, body mass index, serum lipids, and glucose, the odds ratio for the association of the apoE4 allele and GD was significantly (P < 0.05) < 1. Also, genotypes were not correlated with cholesterol crystal formation time, CSI, or gallstone cholesterol content. In contrast to previous smaller studies, apoE polymorphisms were not associated with susceptibility to cholesterol GD in high-risk populations.
dc.fechaingreso.objetodigital2024-05-15
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1194/jlr.M700059-JLR200
dc.identifier.issn0022-2275
dc.identifier.pubmedidMEDLINE:17384433
dc.identifier.urihttps://doi.org/10.1194/jlr.M700059-JLR200
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76052
dc.identifier.wosidWOS:000246659000015
dc.information.autorucMedicina;Miquel J;S/I;72216
dc.information.autorucMedicina;Nervi F;S/I;99156
dc.information.autorucMedicina;Pimentel F;S/I;58222
dc.information.autorucMedicina;Rigotti A;S/I;68489
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final1385
dc.pagina.inicio1378
dc.publisherAMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
dc.revistaJOURNAL OF LIPID RESEARCH
dc.rightsacceso abierto
dc.subjectgallstone disease
dc.subjectcholesterol
dc.subjectgenetic association study
dc.subjectCHOLESTEROL GALLSTONE DISEASE
dc.subjectQUANTITATIVE TRAIT LOCUS
dc.subjectHUMAN GALLBLADDER BILE
dc.subjectE POLYMORPHISM
dc.subjectMEXICAN-AMERICANS
dc.subjectUNITED-STATES
dc.subjectSERUM-LIPIDS
dc.subjectEPIDEMIOLOGY
dc.subjectE4
dc.subjectPROTEINS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGenetic evidence that apolipoprotein E4 is not a relevant susceptibility factor for cholelithiasis in two high-risk populations
dc.typeartículo
dc.volumen48
sipa.codpersvinculados72216
sipa.codpersvinculados99156
sipa.codpersvinculados58222
sipa.codpersvinculados68489
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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