Extensive personal experience - Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents

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dc.contributor.authorMulatero, P
dc.contributor.authorStowasser, M
dc.contributor.authorLoh, KC
dc.contributor.authorFardella, CE
dc.contributor.authorGordon, RD
dc.contributor.authorMosso, L
dc.contributor.authorGomez Sanchez, CE
dc.contributor.authorVeglio, F
dc.contributor.authorYoung, WF
dc.date.accessioned2024-01-10T12:38:55Z
dc.date.available2024-01-10T12:38:55Z
dc.date.issued2004
dc.description.abstractPrimary aldosteronism (PA) is a common form of endocrine hypertension previously believed to account for less than 1% of hypertensive patients. Hypokalemia was considered a prerequisite for pursuing diagnostic tests for PA. Recent studies applying the plasma aldosterone/plasma renin activity ratio (ARR) as a screening test have reported a higher prevalence. This study is a retrospective evaluation of the diagnosis of PA from clinical centers in five continents before and after the widespread use of the ARR as a screening test. The application of this strategy to a greater number of hypertensives led to a 5- to 15-fold increase in the identification of patients affected by PA. Only a small proportion of patients ( between 9 and 37%) were hypokalemic. The annual detection rate of aldosterone-producing adenoma (APA) increased in all centers ( by 1.3-6.3 times) after the wide application of ARR. Aldosterone-producing adenomas constituted a much higher proportion of patients with PA in the four centers that employed adrenal venous sampling ( 28 - 50%) than in the center that did not (9%). In conclusion, the wide use of the ARR as a screening test in hypertensive patients led to a marked increase in the detection rate of PA.
dc.fechaingreso.objetodigital2024-05-15
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1210/jc.2003-031337
dc.identifier.issn0021-972X
dc.identifier.pubmedidMEDLINE:15001583
dc.identifier.urihttps://doi.org/10.1210/jc.2003-031337
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77118
dc.identifier.wosidWOS:000220030700002
dc.information.autorucMedicina;Mosso L;S/I;88201
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1050
dc.pagina.inicio1045
dc.publisherENDOCRINE SOC
dc.revistaJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
dc.rightsacceso restringido
dc.subjectRAT-HEART
dc.subjectPRIMARY HYPERALDOSTERONISM
dc.subjectHYPERTENSIVE PATIENTS
dc.subjectBLOOD-PRESSURE
dc.subjectPREVALENCE
dc.subjectPATHOPHYSIOLOGY
dc.subjectINFLAMMATION
dc.subjectMANAGEMENT
dc.subjectBLOCKER
dc.subjectSYSTEM
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExtensive personal experience - Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents
dc.typeartículo
dc.volumen89
sipa.codpersvinculados88201
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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