Association between leptin receptor (LEPR) and brain-derived neurotrophic factor (BDNF) gene variants and obesity: a case-control study

Simple item page
dc.contributor.authorMarti, A.
dc.contributor.authorSantos, J. L.
dc.contributor.authorGratacos, M.
dc.contributor.authorMoreno Aliaga, M. J.
dc.contributor.authorMaiz, A.
dc.contributor.authorMartinez, J. A.
dc.contributor.authorEstivill, X.
dc.date.accessioned2024-01-10T12:04:22Z
dc.date.available2024-01-10T12:04:22Z
dc.date.issued2009
dc.description.abstractIntroduction: Human and animal studies provide evidence for a relevant role of the leptin receptor (LEPR) and the brain-derived neurotrophic factor (BDNF) genes in energy homeostasis.
dc.description.abstractAim: To assess the association between human LEPR and BDNF genetic variants with adult obesity. Design and methods: Case-control study in Pamplona (Navarra, Spain) with adult obese subjects (n = 159) and normal weight controls (n = 154) Four common polymorphisms of the LEPR gene (Lys109Arg, Gln223Arg, Ser34Ser, Lys656Asn) and 17 variants of the BDNF gene, including the Val66Met variant, were genotyped.
dc.description.abstractResults: No significant case-control differences were found in allele/genotype frequencies after adjusting for relevant co-variates. Haplotype analysis did not detect any significant association between LEPR or BDNF variants and obesity. No associations were found between LEPR variants and serum leptin levels.
dc.description.abstractConclusions: Our results do not support a major role of LEPR or BDNF common polymorphisms in multifactorial adult obesity.
dc.fechaingreso.objetodigital2024-05-15
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1179/147683009X423355
dc.identifier.eissn1476-8305
dc.identifier.issn1028-415X
dc.identifier.pubmedidMEDLINE:19622243
dc.identifier.urihttps://doi.org/10.1179/147683009X423355
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75775
dc.identifier.wosidWOS:000267975700007
dc.information.autorucMedicina;Maiz A;S/I;99116
dc.information.autorucMedicina;Santos JL;S/I;1005923
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final188
dc.pagina.inicio183
dc.publisherTAYLOR & FRANCIS LTD
dc.revistaNUTRITIONAL NEUROSCIENCE
dc.rightsacceso restringido
dc.subjectobesity
dc.subjectleptin receptor
dc.subjectbrain-derived neurotrophic factor
dc.subjectcase-control study
dc.subjectBODY-MASS INDEX
dc.subjectANOREXIA-NERVOSA
dc.subjectWEIGHT
dc.subjectRISK
dc.subjectSPECTRUM
dc.subjectEXTREME
dc.subjectLINKAGE
dc.subjectGAIN
dc.subject.ods03 Good Health and Well-being
dc.subject.ods02 Zero Hunger
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa02 Hambre cero
dc.titleAssociation between leptin receptor (LEPR) and brain-derived neurotrophic factor (BDNF) gene variants and obesity: a case-control study
dc.typeartículo
dc.volumen12
sipa.codpersvinculados99116
sipa.codpersvinculados1005923
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2024-05-15. Association between leptin receptor (LEPR) and brain-derived neurotrophic factor (BDNF) gene variants and obesity - a case-control study.pdf
Size:
2.74 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas