Use of autologous platelet derivatives for secondary alveoloplasty in patients with cleft lip and palate: a systematic review and meta-analysis

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dc.catalogadoryvc
dc.contributor.authorCampolo González, Andrés Francisco
dc.contributor.authorHeider Contreras, Claudia Andrea
dc.contributor.authorVerdugo Paiva, M. F.
dc.contributor.authorBravo Jeria, R.
dc.contributor.authorMorovic, C. G.
dc.contributor.authorRada, G.
dc.date.accessioned2024-11-21T21:27:42Z
dc.date.available2024-11-21T21:27:42Z
dc.date.issued2024
dc.description.abstractThis study aimed to evaluate the effectiveness of autologous platelet derivatives (APD), specifically platelet-rich plasma (PRP) or platelet-rich fibrin (PRF), combined with autogenous iliac crest bone grafts in secondary alveoloplasty for patients with cleft lip and palate. Electronic databases, relevant journals, and reference lists of included studies were searched until July 2022. Best-evidence synthesis was performed to draw conclusions. After the search strategies, 12 randomized controlled trials were included that provided data on six outcomes: newly formed bone, mean bone loss in height and width, bone density, functionality, and postoperative complications. Two authors independently assessed the risk of bias, and the certainty of evidence was assessed using the GRADE approach. The pooled results suggest that there is uncertainty as to whether the combination of APDs with autogenous iliac crest bone grafts improves the percentage of newly formed bone, as the certainty of the evidence was assessed as very low. It may slightly improve the functionality of patients (with low certainty of the evidence) and probably slightly reduces the incidence of postoperative complications (with moderate certainty of evidence). Further randomized clinical trials with standardized methodologies are required to validate these findings.
dc.format.extent10 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1016/j.ijom.2023.08.008
dc.identifier.issn1399-0020
dc.identifier.scopusidScopus_ID: 85171851009
dc.identifier.urihttps://doi.org/10.1016/j.ijom.2023.08.008
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88639
dc.information.autorucEscuela de Medicina;Campolo González, Andrés Francisco; S/I; 1015697
dc.information.autorucEscuela de Medicina; Heider Contreras, Claudia Andrea; 0000-0003-1111-4380; 238023
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final27
dc.pagina.inicio18
dc.publisherChurchill Livingstone
dc.revistaInternational Journal of Oral & Maxillofacial Surgery
dc.rightsacceso restringido
dc.subjectAlveolar bone grafting
dc.subjectAlveoloplasty
dc.subjectCleft lip
dc.subjectCleft palate
dc.subjectMeta analysis
dc.subjectPlatelet rich fibrin
dc.subjectPlatelet rich plasma
dc.subjectSystematic review
dc.subject.ddc610
dc.subject.ods03 Good Health and Well-Being
dc.subject.odspa03 Salud y Bienestar
dc.titleUse of autologous platelet derivatives for secondary alveoloplasty in patients with cleft lip and palate: a systematic review and meta-analysis
dc.typeartículo
dc.volumen53
sipa.codpersvinculados1015697
sipa.codpersvinculados238023
sipa.trazabilidadScopus;2023-10-15
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