Older age does not influence CD4 cell recovery in HIV-1 infected patients receiving Highly Active Anti Retroviral Therapy

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dc.contributor.authorTumbarello, Mario.
dc.contributor.authorRabagliati, Ricardo
dc.contributor.authorde Gaetano Donati, Katleen.
dc.contributor.authorBertagnolio, Silvia.
dc.contributor.authorMontuori, Eva.
dc.contributor.authorTamburrini, Enrica.
dc.contributor.authorTacconelli, Evelina.
dc.contributor.authorCauda, Roberto.
dc.date.accessioned2019-10-17T18:19:14Z
dc.date.available2019-10-17T18:19:14Z
dc.date.issued2004
dc.date.updated2019-10-14T18:28:43Z
dc.description.abstractAbstract Background Diagnosis of HIV infection is recently occurring with increasing frequency in middle-aged and in older individuals. As HAART became available, a minimal beneficial effect on immunological outcome in older in respect of younger subjects has been reported. In fact, both the intensity and the rapidity of the immunological response appeared to be reduced in elderly subjects. On the contrary, only few reports have indicated a similar immunological outcome both in older and younger HIV-positive subjects. Interestingly, older age did not seem to significantly affect the long-term virological outcome of HAART treated subjects. Methods To characterise epidemiological and clinical features of older HIV+ subjects, a prospective case-control study was performed: 120 subjects ≥ 50 and 476 between 20 and 35 years were initially compared. Subsequently, to better define the impact of HAART on their viro-immunological response, 81 older were compared with 162 younger subjects. Results At baseline cases presented significantly lower TCD4+ cell number and were more frequently affected by comorbid conditions. Under HAART a statistically significant increase in TCD4+ cell number was observed in cases and controls. At multivariate analysis, there was no statistically significant difference between cases and controls regarding viro-immunological response. Conclusions Although older subjects present a more severe HIV infection, they can achieve, under HAART, the same viro-immunological success as the younger individuals.
dc.fuente.origenBiomed Central
dc.identifier.citationBMC Infectious Diseases. 2004 Nov 06;4(1):46
dc.identifier.doi10.1186/1471-2334-4-46
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26812
dc.issue.numeroNo. 46
dc.language.isoen
dc.pagina.final11
dc.pagina.inicio1
dc.revistaBMC Infectious Diseaseses_ES
dc.rightsacceso abierto
dc.rights.holderTumbarello et al; licensee BioMed Central Ltd.
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherVirus de inmunodeficiencia humanaes_ES
dc.subject.otherVIH - Chile -Diagnósticoes_ES
dc.subject.otherVIH - Chile -Terapiaes_ES
dc.titleOlder age does not influence CD4 cell recovery in HIV-1 infected patients receiving Highly Active Anti Retroviral Therapyes_ES
dc.typeartículo
dc.volumenVol. 4
sipa.codpersvinculados59169
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