Transmission of gram-negative antibiotic-resistant bacteria following differing exposure to antibiotic-resistance reservoirs in a rural community: a modelling study for bloodstream infections

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dc.contributor.authorAllel, Kasim
dc.contributor.authorGosce, Lara
dc.contributor.authorAraos, Rafael
dc.contributor.authorToro, Daniel
dc.contributor.authorFerreccio, Catterina
dc.contributor.authorMunita, Jose M.
dc.contributor.authorUndurraga, Eduardo A.
dc.contributor.authorPanovska-Griffiths, Jasmina
dc.date.accessioned2024-01-10T13:45:21Z
dc.date.available2024-01-10T13:45:21Z
dc.date.issued2022
dc.description.abstractExposure to community reservoirs of gram-negative antibiotic-resistant bacteria (GN-ARB) genes poses substantial health risks to individuals, complicating potential infections. Transmission networks and population dynamics remain unclear, particularly in resource-poor communities. We use a dynamic compartment model to assess GN-ARB transmission quantitatively, including the susceptible, colonised, infected, and removed populations at the community-hospital interface. We used two side streams to distinguish between individuals at high- and low-risk exposure to community ARB reservoirs. The model was calibrated using data from a cross-sectional cohort study (N = 357) in Chile and supplemented by existing literature. Most individuals acquired ARB from the community reservoirs (98%) rather than the hospital. High exposure to GN-ARB reservoirs was associated with 17% and 16% greater prevalence for GN-ARB carriage in the hospital and community settings, respectively. The higher exposure has led to 16% more infections and attributed mortality. Our results highlight the need for early-stage identification and testing capability of bloodstream infections caused by GN-ARB through a faster response at the community level, where most GN-ARB are likely to be acquired. Increasing treatment rates for individuals colonised or infected by GN-ARB and controlling the exposure to antibiotic consumption and GN-ARB reservoirs, is crucial to curve GN-ABR transmission.
dc.fechaingreso.objetodigital2024-04-25
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41598-022-17598-x
dc.identifier.issn2045-2322
dc.identifier.urihttps://doi.org/10.1038/s41598-022-17598-x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79020
dc.identifier.wosidWOS:000836707300011
dc.information.autorucInterdisciplinarias; Undurraga Fourcade, Eduardo Andres; S/I; 12868
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherNATURE PORTFOLIO
dc.revistaSCIENTIFIC REPORTS
dc.rightsacceso abierto
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTransmission of gram-negative antibiotic-resistant bacteria following differing exposure to antibiotic-resistance reservoirs in a rural community: a modelling study for bloodstream infections
dc.typeartículo
dc.volumen12
sipa.codpersvinculados12868
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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