Regulation of Pain Perception by Microbiota in Parkinson Disease
dc.catalogador | gjm | |
dc.contributor.author | Manjarres Farías, Zulmary Alicia | |
dc.contributor.author | Calvo Bascuñán, Margarita | |
dc.contributor.author | Pacheco, Rodrigo | |
dc.date.accessioned | 2023-12-19T14:33:35Z | |
dc.date.available | 2023-12-19T14:33:35Z | |
dc.date.issued | 2024 | |
dc.description.abstract | Pain perception involves current stimulation in peripheral nociceptive nerves and the subsequent stimulation of postsynaptic excitatory neurons in the spinal cord. Importantly, in chronic pain, the neural activity of both peripheral nociceptors and postsynaptic neurons in the central nervous system is influenced by several inflammatory mediators produced by the immune system. Growing evidence has indicated that the commensal microbiota plays an active role in regulating pain perception by either acting directly on nociceptors or indirectly through the modulation of the inflammatory activity on immune cells. This symbiotic relationship is mediated by soluble bacterial mediators or intrinsic structural components of bacteria that act on eukaryotic cells, including neurons, microglia, astrocytes, macrophages, T cells, enterochromaffin cells, and enteric glial cells. The molecular mechanisms involve bacterial molecules that act directly on neurons, affecting their excitability, or indirectly on non-neuronal cells, inducing changes in the production of proinflammatory or anti-inflammatory mediators. Importantly, Parkinson disease, a neurodegenerative and inflammatory disorder that affects mainly the dopaminergic neurons implicated in the control of voluntary movements, involves not only a motor decline but also nonmotor symptomatology, including chronic pain. Of note, several recent studies have shown that Parkinson disease involves a dysbiosis in the composition of the gut microbiota. In this review, we first summarize, integrate, and classify the molecular mechanisms implicated in the microbiota-mediated regulation of chronic pain. Second, we analyze the changes on the commensal microbiota associated to Parkinson disease and propose how these changes affect the development of chronic pain in this pathology. | |
dc.fechaingreso.objetodigital | 2023-12-19 | |
dc.fuente.origen | ORCID | |
dc.identifier.doi | 10.1124/pharmrev.122.000674 | |
dc.identifier.issn | 1521-0081 | |
dc.identifier.uri | http://dx.doi.org/10.1124/pharmrev.122.000674 | |
dc.identifier.uri | https://repositorio.uc.cl/handle/11534/75529 | |
dc.information.autoruc | Facultad de Ciencias Biológicas; Manjarres Farías, Zulmary Alicia; S/I; 1092045 | |
dc.information.autoruc | Facultad de Ciencias Biológicas; Calvo Bascuñán, Margarita; 0000-0003-3349-9189; 3457 | |
dc.language.iso | en | |
dc.nota.acceso | Contenido parcial | |
dc.pagina.final | 36 | |
dc.pagina.inicio | 7 | |
dc.revista | Pharmacological Reviews | |
dc.rights | acceso restringido | |
dc.subject.ddc | 570 | |
dc.subject.dewey | Biología | es_ES |
dc.title | Regulation of Pain Perception by Microbiota in Parkinson Disease | |
dc.type | artículo | |
dc.volumen | 76 | |
sipa.codpersvinculados | 1092045 | |
sipa.codpersvinculados | 3457 | |
sipa.trazabilidad | ORCID;2023-12-18 |
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