Regulation of Pain Perception by Microbiota in Parkinson Disease

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dc.catalogadorgjm
dc.contributor.authorManjarres Farías, Zulmary Alicia
dc.contributor.authorCalvo Bascuñán, Margarita
dc.contributor.authorPacheco, Rodrigo
dc.date.accessioned2023-12-19T14:33:35Z
dc.date.available2023-12-19T14:33:35Z
dc.date.issued2024
dc.description.abstractPain perception involves current stimulation in peripheral nociceptive nerves and the subsequent stimulation of postsynaptic excitatory neurons in the spinal cord. Importantly, in chronic pain, the neural activity of both peripheral nociceptors and postsynaptic neurons in the central nervous system is influenced by several inflammatory mediators produced by the immune system. Growing evidence has indicated that the commensal microbiota plays an active role in regulating pain perception by either acting directly on nociceptors or indirectly through the modulation of the inflammatory activity on immune cells. This symbiotic relationship is mediated by soluble bacterial mediators or intrinsic structural components of bacteria that act on eukaryotic cells, including neurons, microglia, astrocytes, macrophages, T cells, enterochromaffin cells, and enteric glial cells. The molecular mechanisms involve bacterial molecules that act directly on neurons, affecting their excitability, or indirectly on non-neuronal cells, inducing changes in the production of proinflammatory or anti-inflammatory mediators. Importantly, Parkinson disease, a neurodegenerative and inflammatory disorder that affects mainly the dopaminergic neurons implicated in the control of voluntary movements, involves not only a motor decline but also nonmotor symptomatology, including chronic pain. Of note, several recent studies have shown that Parkinson disease involves a dysbiosis in the composition of the gut microbiota. In this review, we first summarize, integrate, and classify the molecular mechanisms implicated in the microbiota-mediated regulation of chronic pain. Second, we analyze the changes on the commensal microbiota associated to Parkinson disease and propose how these changes affect the development of chronic pain in this pathology.
dc.fechaingreso.objetodigital2023-12-19
dc.fuente.origenORCID
dc.identifier.doi10.1124/pharmrev.122.000674
dc.identifier.issn1521-0081
dc.identifier.urihttp://dx.doi.org/10.1124/pharmrev.122.000674
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75529
dc.information.autorucFacultad de Ciencias Biológicas; Manjarres Farías, Zulmary Alicia; S/I; 1092045
dc.information.autorucFacultad de Ciencias Biológicas; Calvo Bascuñán, Margarita; 0000-0003-3349-9189; 3457
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final36
dc.pagina.inicio7
dc.revistaPharmacological Reviews
dc.rightsacceso restringido
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.titleRegulation of Pain Perception by Microbiota in Parkinson Disease
dc.typeartículo
dc.volumen76
sipa.codpersvinculados1092045
sipa.codpersvinculados3457
sipa.trazabilidadORCID;2023-12-18
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