Association between public health policies on alcohol and worldwide cancer, liver disease and cardiovascular disease outcomes

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dc.catalogadorvzp
dc.contributor.authorDiaz Piga, Luis Antonio
dc.contributor.authorFuentes, López Eduardo
dc.contributor.authorIdalsoaga Ferrer, Francisco Javier
dc.contributor.authorAyares Campos, Gustavo Ignacio
dc.contributor.authorCorsi Sotelo, Oscar Felipe
dc.contributor.authorArnold Alvarez, Jorge Ignacio
dc.contributor.authorCannistra Cadiz, Macarena Rossella
dc.contributor.authorVio Quiroz, Danae Fernanda
dc.contributor.authorMarquez Lomas, Andrea
dc.contributor.authorRamirez Cadiz, Carolina Andrea
dc.contributor.authorMedel Salas, María Paz
dc.contributor.authorHernández Tejero, María
dc.contributor.authorFerreccio Readi, Fresia Catterina
dc.contributor.authorLazo Bravo, Mariana Carolina
dc.contributor.authorRoblero Cum, Juan Pablo
dc.contributor.authorCotter, Thomas G.
dc.contributor.authorKulkarni ,Anand V.
dc.contributor.authorKim, Won
dc.contributor.authorBrahmania, Mayur
dc.contributor.authorLouvet, Alexandre
dc.contributor.authorTapper, Elliot B.
dc.contributor.authorDunn, Winston
dc.contributor.authorSimonetto, Douglas
dc.contributor.authorShah, Vijay H.
dc.contributor.authorKamath, Patrick S.
dc.contributor.authorLazarus, Jeffrey V.
dc.contributor.authorSingal, Ashwabi K.
dc.contributor.authorBataller, Ramón
dc.contributor.authorArrese Jimenez, Marco Antonio
dc.contributor.authorArab Verdugo, Juan Pablo
dc.date.accessioned2024-01-26T17:34:26Z
dc.date.available2024-01-26T17:34:26Z
dc.date.issued2023
dc.description.abstract© 2023 The Author(s)Background & Aims: The long-term impact of alcohol-related public health policies (PHPs) on disease burden is unclear. We aimed to assess the association between alcohol-related PHPs and alcohol-related health consequences. Methods: We conducted an ecological multi-national study including 169 countries. We collected data on alcohol-related PHPs from the WHO Global Information System of Alcohol and Health 2010. Data on alcohol-related health consequences between 2010–2019 were obtained from the Global Burden of Disease database. We classified PHPs into five items, including criteria for low, moderate, and strong PHP establishment. We estimated an alcohol preparedness index (API) using multiple correspondence analysis (0 lowest and 100 highest establishment). We estimated an incidence rate ratio (IRR) for outcomes according to API using adjusted multilevel generalized linear models with a Poisson family distribution. Results: The median API in the 169 countries was 54 [IQR 34.9–76.8]. The API was inversely associated with alcohol use disorder (AUD) prevalence (IRR 0.13; 95% CI 0.03–0.60; p = 0.010), alcohol-associated liver disease (ALD) mortality (IRR 0.14; 95% CI 0.03–0.79; p = 0.025), mortality due to neoplasms (IRR 0.09; 95% CI 0.02–0.40; p = 0.002), alcohol-attributable hepatocellular carcinoma (HCC) (IRR 0.13; 95% CI 0.02–0.65; p = 0.014), and cardiovascular diseases (IRR 0.09; 95% CI 0.02–0.41; p = 0.002). The highest associations were observed in the Americas, Africa, and Europe. These associations became stronger over time, and AUD prevalence was significantly lower after 2 years, while ALD mortality and alcohol-attributable HCC incidence decreased after 4 and 8 years from baseline API assessment, respectively (p <0.05). Conclusions: The API is a valuable instrument to quantify the robustness of alcohol-related PHP establishment. Lower AUD prevalence and lower mortality related to ALD, neoplasms, alcohol-attributable HCC, and cardiovascular diseases were observed in countries with a higher API. Our results encourage the development and strengthening of alcohol-related policies worldwide. Impact and implications: We first developed an alcohol preparedness index, an instrument to assess the existence of alcohol-related public policies for each country. We then evaluated the long-term association of the country's alcohol preparedness index in 2010 with the burden of chronic liver disease, hepatocellular carcinoma, other neoplasms, and cardiovascular disease. The strengthening of alcohol-related public health policies could impact long-term mortality rates from cardiovascular disease, neoplasms, and liver disease. These conditions are the main contributors to the global burden of disease related to alcohol use. Over time, this association has not only persisted but also grown stronger. Our results expand the preliminary evidence regarding the importance of public health policies in controlling alcohol-related health consequences.
dc.description.funderCOLMED
dc.description.funderColegio Médico de Chile
dc.description.funderFondo Nacional de Desarrollo Científico y Tecnológico
dc.fechaingreso.objetodigital2024-06-10
dc.format.extent10 páginas
dc.fuente.origenSCOPUS
dc.identifier.doi10.1016/j.jhep.2023.11.006
dc.identifier.issn16000641 01688278
dc.identifier.scopusidSCOPUS_ID:85180594670
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80993
dc.information.autorucEscuela de Medicina; Diaz Piga Luis Antonio; S/I ; 179253
dc.information.autorucEscuela de Medicina; Fuentes Lopez Eduardo; 0000-0002-0141-0226; 1013849
dc.information.autorucEscuela de Medicina; Idalsoaga Ferrer Francisco Javier; S/I ; 1017394
dc.information.autorucEscuela de Medicina; Ayares Campos Gustavo Ignacio; S/I ; 1033904
dc.information.autorucEscuela de Medicina; Corsi Sotelo Oscar Felipe; S/I ; 187191
dc.information.autorucEscuela de Medicina; Arnold Alvarez Jorge Ignacio; S/I ; 1148388
dc.information.autorucEscuela de Medicina; Cannistra Cadiz Macarena Rossella; S/I ; 223901
dc.information.autorucEscuela de Medicina; Vio Quiroz Danae Fernanda; S/I ; 1028045
dc.information.autorucEscuela de Medicina; Ramirez Cadiz Carolina Andrea; S/I ; 149952
dc.information.autorucEscuela de Medicina; Medel Salas Maria Paz; S/I; 1034385
dc.information.autorucEscuela de Medicina; Ferreccio Readi Fresia Catterina; 0000-0001-6331-5534; 99684
dc.information.autorucInstituto de Geografía; Lazo Bravo Mariana Carolina; S/I ; 213064
dc.information.autorucEscuela de Medicina; Roblero Cum Juan Pablo; S/I; 62455
dc.information.autorucEscuela de Medicina; Arrese Jimenez Marco Antonio; 0000-0002-0499-4191; 76095
dc.information.autorucEscuela de Medicina; Arab Verdugo Juan Pablo; 0000-0002-8561-396X; 132745
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final10
dc.pagina.inicio1
dc.publisherElsevier B.V.
dc.revistaJournal of Hepatology
dc.rightsacceso abierto
dc.rights.licenseAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/deed.en
dc.subjectAlcohol use disorder
dc.subjectAlcohol-associated liver disease
dc.subjectAlcoholic liver disease
dc.subjectCirrhosis
dc.subjectEthanol
dc.subjectNeoplasms
dc.subject.ddc610
dc.subject.deweyMedicina y salud
dc.titleAssociation between public health policies on alcohol and worldwide cancer, liver disease and cardiovascular disease outcomes
dc.typeJournal
sipa.codpersvinculados179253
sipa.codpersvinculados1013849
sipa.codpersvinculados1017394
sipa.codpersvinculados1033904
sipa.codpersvinculados187191
sipa.codpersvinculados1148388
sipa.codpersvinculados223901
sipa.codpersvinculados1028045
sipa.codpersvinculados149952
sipa.codpersvinculados1034385
sipa.codpersvinculados99684
sipa.codpersvinculados213064
sipa.codpersvinculados62455
sipa.codpersvinculados76095
sipa.codpersvinculados132745
sipa.trazabilidadSCOPUS;2024-01-14
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