Follicular Cholecystitis: Reappraisal of Incidence, Definition, and Clinicopathologic Associations in an Analysis of 2550 Cholecystectomies

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dc.contributor.authorSaka, Burcu
dc.contributor.authorMemis, Bahar
dc.contributor.authorSeven, Ipek Erbarut
dc.contributor.authorPehlivanoglu, Burcin
dc.contributor.authorBalci, Serdar
dc.contributor.authorBagci, Pelin
dc.contributor.authorReid, Michelle
dc.contributor.authorDursun, Nevra
dc.contributor.authorTapia Escalano, Oscar
dc.contributor.authorCarlos Roa, Juan
dc.contributor.authorCarlos Araya, Juan
dc.contributor.authorKong, So Yeon
dc.contributor.authorBasturk, Olca
dc.contributor.authorKoshiol, Jill
dc.contributor.authorAdsay, N. Volkan
dc.date.accessioned2024-01-10T12:39:02Z
dc.date.available2024-01-10T12:39:02Z
dc.date.issued2020
dc.description.abstractContext.
dc.description.abstractFollicular cholecystitis (FC) is a poorly characterized entity.
dc.description.abstractObjective.
dc.description.abstractTo determine its frequency/clinicopathologic associations.
dc.description.abstractDesign.
dc.description.abstractA total of 2550 cholecystectomy specimens were examined. Two hundred three of these were consecutive routine cholecystectomies submitted entirely for microscopic examination to determine the relative frequency of incidental pathologies in gallbladders (GBs). The remainder had representative sampling. Underlying conditions were nonobstructive pathologies (1270 nonspecific cholecystitis), obstructive (62 distal biliary tract tumors, 35 primary sclerosing cholangitis, and 31 autoimmune pancreatitis), and neoplastic (n = 949). FC was defined as 3 distinct lymphoid follicles (LFs)/centimeter.
dc.description.abstractResults.
dc.description.abstractIn the GBs totally submitted for microscopic examination, the true frequency of FC was found to be 2.5% (5/203), and in the representatively sampled group, it was 1.9%, with similar frequencies in nonobstructive, obstructive, and neoplastic cases (2.3%, 3.1%, and 1.3%, respectively, P = .77). When the 39 FC in nonneoplastic GBs contrasted with ordinary chronic cholecystitis, they were associated with older age (68 vs 49 years, P < .0001), similar gallstone frequency (68 vs 81%), female/male ratio (2.7 vs 2.6), and wall thickness (4 mm for both). None had lymphoma/parasites/Salmonella infection. Of 17 cases who had undergone gastric biopsy, 5 had chronic gastritis (2 with Helicobacter pylori). Microscopically, the LFs were the main inflammatory process often with minimal intervening inflammation. IgG4-positive plasma cell density was low (<10/high-power field) in 21/24(87.5%) cases.
dc.description.abstractConclusions.
dc.description.abstractFollicular cholecystitis is seen in 2% of cholecystectomies, typically in significantly older patients, suggesting a deranged immune response. A third of the patients reveal biopsy-proven gastritis. FC does not seem to be associated with autoimmunity, lymphoma, or obstructive pathologies.
dc.fechaingreso.objetodigital2024-05-14
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1177/1066896920924079
dc.identifier.eissn1940-2465
dc.identifier.issn1066-8969
dc.identifier.pubmedidMEDLINE:32423360
dc.identifier.urihttps://doi.org/10.1177/1066896920924079
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77137
dc.identifier.wosidWOS:000534596700001
dc.information.autorucMedicina;Juan Carlos Roa;S/I;84743
dc.issue.numero8
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final834
dc.pagina.inicio826
dc.publisherSAGE PUBLICATIONS INC
dc.revistaINTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
dc.rightsacceso restringido
dc.subjectcholecystectomy
dc.subjectfollicular cholecystitis
dc.subjecthistology
dc.subjectLYMPHOPLASMACYTIC CHRONIC CHOLECYSTITIS
dc.subjectBILIARY-TRACT DISEASE
dc.subjectHELICOBACTER-PYLORI
dc.subjectDISTINCTIVE FORM
dc.subjectGALLBLADDER
dc.subjectPANCREATITIS
dc.subjectAUTOIMMUNE
dc.subjectPREVALENCE
dc.subjectMUCOSA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFollicular Cholecystitis: Reappraisal of Incidence, Definition, and Clinicopathologic Associations in an Analysis of 2550 Cholecystectomies
dc.typeartículo
dc.volumen28
sipa.codpersvinculados84743
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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