SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics

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dc.catalogadorjlo
dc.contributor.authorPrieto Villalobos, Juan Carlos
dc.contributor.authorLucero, Claudia M.
dc.contributor.authorRovegno, Maximiliano
dc.contributor.authorGómez, Gonzalo I.
dc.contributor.authorRetamal, Mauricio A.
dc.contributor.authorOrellana Roca, Juan Andrés
dc.date.accessioned2023-11-10T17:45:06Z
dc.date.available2023-11-10T17:45:06Z
dc.date.issued2023
dc.description.abstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19). An aspect of high uncertainty is whether the SARS-CoV-2 per se or the systemic inflammation induced by viral infection directly affects cellular function and survival in different tissues. It has been postulated that tissue dysfunction and damage observed in COVID-19 patients may rely on the direct effects of SARS-CoV-2 viral proteins. Previous evidence indicates that the human immunodeficiency virus and its envelope protein gp120 increase the activity of connexin 43 (Cx43) hemichannels with negative repercussions for cellular function and survival. Here, we evaluated whether the spike protein S1 of SARS-CoV-2 could impact the activity of Cx43 hemichannels.
dc.fechaingreso.objetodigital2023-10-30
dc.format.extent14 páginas
dc.fuente.origenSIPA
dc.identifier.doi10.1186/s40659-023-00468-9
dc.identifier.issn0717-6287
dc.identifier.urihttps://doi.org/10.1186/s40659-023-00468-9
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75283
dc.information.autorucEscuela de Medicina; Prieto Villalobos, Juan Carlos; 0000-0002-5260-5170; 1071673
dc.information.autorucEscuela de Medicina; Orellana Roca, Juan Andrés; 0000-0003-4076-207X; 126007
dc.issue.numero56
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final14
dc.pagina.inicio1
dc.revistaBiological Research
dc.rightsacceso abierto
dc.subjectHemichannels
dc.subjectCOVID-19
dc.subjectConnexin 43
dc.subjectSARS-CoV-2
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleSARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics
dc.typeartículo
sipa.codpersvinculados1071673
sipa.codpersvinculados126007
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