Biogeographical variation in antimicrobial resistance in rivers is influenced by agriculture and is spread through bacteriophages

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dc.contributor.authorAndersson, Tilde
dc.contributor.authorAdell, Aiko D.
dc.contributor.authorMoreno-Switt, Andrea I.
dc.contributor.authorSpegel, Peter
dc.contributor.authorTurner, Charlotta
dc.contributor.authorOverballe-Petersen, Soren
dc.contributor.authorFuursted, Kurt
dc.contributor.authorLood, Rolf
dc.date.accessioned2024-01-10T12:37:16Z
dc.date.available2024-01-10T12:37:16Z
dc.date.issued2022
dc.description.abstractAntibiotic resistance is currently an extensive medical challenge worldwide, with global numbers increasing steadily. Recent data have highlighted wastewater treatment plants as a reservoir of resistance genes. The impact of these findings for human health can best be summarized using a One Health concept. However, the molecular mechanisms impacting resistance spread have not been carefully evaluated. Bacterial viruses, that is bacteriophages, have recently been shown to be important mediators of bacterial resistance genes in environmental milieus and are transferrable to human pathogens. Herein, we investigated the biogeographical impact on resistance spread through river-borne bacteriophages using amplicon deep sequencing of the microbiota, absolute quantification of resistance genes using ddPCR, and phage induction capacity within wastewater. Microbial biodiversity of the rivers is significantly affected by river site, surrounding milieu and time of sampling. Furthermore, areas of land associated with agriculture had a significantly higher ability to induce bacteriophages carrying antibiotic resistance genes, indicating their impact on resistance spread. It is imperative that we continue to analyse global antibiotic resistance problem from a One Health perspective to gain novel insights into mechanisms of resistance spread.
dc.fechaingreso.objetodigital2024-05-28
dc.fuente.origenWOS
dc.identifier.doi10.1111/1462-2920.16122
dc.identifier.eissn1462-2920
dc.identifier.issn1462-2912
dc.identifier.urihttps://doi.org/10.1111/1462-2920.16122
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76800
dc.identifier.wosidWOS:000821696000001
dc.information.autorucFacultad de Agronomía e Ingeniería Forestal; Moreno Switt, Andrea Isabel; S/I; 1147061
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherWILEY
dc.revistaENVIRONMENTAL MICROBIOLOGY
dc.rightsacceso abierto
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBiogeographical variation in antimicrobial resistance in rivers is influenced by agriculture and is spread through bacteriophages
dc.typeartículo
sipa.codpersvinculados1147061
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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