Binge-like Alcohol Administration Alters Decision Making in an Adolescent Rat Model: Role of N-Methyl-D-Aspartate Receptor Signaling

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dc.catalogadorgjm
dc.contributor.authorArce Olave, Camila Raquel
dc.contributor.authorMira Guzmán, Rodrigo Andrés
dc.contributor.authorLira Mendieta, Matías Sebastián
dc.contributor.authorCerpa Nebott, Waldo Francisco
dc.date.accessioned2024-01-30T15:23:30Z
dc.date.available2024-01-30T15:23:30Z
dc.date.issued2023
dc.description.abstractAlcohol is one of the most used legal drugs abused worldwide, and its consumption is associated with high mortality and morbidity rates. There is an increasing concern about the starting age of consumption of this drug since it has become evident that it is at younger ages. The so-called “pattern of consumption by binge” corresponds to ingesting large amounts of alcohol in a short period and is the most popular among young people. Previous studies show that alcohol causes damage in different areas, such as the hippocampus, hypothalamus, and prefrontal cortex, and adolescents are more susceptible to alcohol toxicity. Alcohol inhibits the membrane glutamate receptor, NMDA-type glutamate receptors (NMDAR). Using a binge-like alcohol administration protocol in adolescent rats (PND25), we investigate decision making through the attentional set-shifting test (ASST) and alterations in the NMDAR signaling in related areas. We observe an impairment in executive function without alterations in NMDAR abundance. However, binge alcohol changes NMDAR signaling and decreases quantity in the synapse, mainly in the hippocampus and hypothalamus. We suggest that prefrontal cortex impairment could arise from damaged connections with the hippocampus and hypothalamus, affecting the survival pathway and memory and learning process.
dc.fuente.origenORCID
dc.identifier.doi10.3390/stresses4010001
dc.identifier.urihttps://doi.org/10.3390/stresses4010001
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81067
dc.information.autorucFacultad de Ciencias Biológicas; Arce Olave, Camila Raquel; S/I; 224241
dc.information.autorucFacultad de Ciencias Biológicas; Mira Guzmán, Rodrigo Andrés; S/I; 215451
dc.information.autorucFacultad de Ciencias Biológicas; Lira Mendieta, Matías Sebastián; S/I; 1050702
dc.information.autorucFacultad de Ciencias Biológicas; Cerpa Nebott, Waldo Francisco; 0000-0001-7344-0144; 16584
dc.language.isoen
dc.nota.accesoContenido completo
dc.rightsacceso abierto
dc.subjectBinge-drinking
dc.subjectAlcohol
dc.subjectNMDA receptor
dc.subjectDecision making
dc.subjectNMDAR signaling
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.titleBinge-like Alcohol Administration Alters Decision Making in an Adolescent Rat Model: Role of N-Methyl-D-Aspartate Receptor Signaling
dc.typeartículo
sipa.codpersvinculados224241
sipa.codpersvinculados215451
sipa.codpersvinculados1050702
sipa.codpersvinculados16584
sipa.trazabilidadORCID;2024-01-15
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