Eccentric Training in Pulmonary Rehabilitation of Post-COVID-19 Patients: An Alternative for Improving the Functional Capacity, Inflammation, and Oxidative Stress

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dc.article.number1446
dc.article.number1446
dc.catalogadorjca
dc.contributor.authorContreras Briceno Felipe
dc.contributor.authorEspinosa Ramirez, Maximiliano Andres
dc.contributor.authorRozenberg, Dmitry
dc.contributor.authorReid, W Darlene
dc.date.accessioned2024-01-22T19:55:12Z
dc.date.available2024-01-22T19:55:12Z
dc.date.issued2022
dc.description.abstractThe purpose of this narrative review is to highlight the oxidative stress induced in COVID-19 patients (SARS-CoV-2 infection), describe longstanding functional impairments, and provide the pathophysiologic rationale that supports aerobic eccentric (ECC) exercise as a novel alternative to conventional concentric (CONC) exercise for post-COVID-19 patients. Patients who recovered from moderate-to-severe COVID-19 respiratory distress demonstrate long–term functional impairment. During the acute phase, SARS-CoV-2 induces the generation of reactive oxygen species that can be amplified to a “cytokine storm”. The resultant inflammatory and oxidative stress process causes organ damage, particularly in the respiratory system, with the lungs as the tissues most susceptible to injury. The acute illness often requires a long-term hospital stay and consequent sarcopenia. Upon discharge, muscle weakness compounded by limited lung and cardiac function is often accompanied by dyspnea, myalgia, anxiety, depression, and sleep disturbance. Consequently, these patients could benefit from pulmonary rehabilitation (PR), with exercise as a critical intervention (including sessions of strength and endurance or aerobic exercises). Unfortunately, conventional CONC exercises induce significant cardiopulmonary stress and increase inflammatory and oxidative stress (OS) when performed at moderate/high intensity, which can exacerbate debilitating dyspnoea and muscle fatigue post-COVID-19. Eccentric training (ECC) is a well–tolerated alternative that improves muscle mass while mitigating cardiopulmonary stress in patients with COPD and other chronic diseases. Similar benefits could be realized in post-COVID-19 patients. Consequently, these patients could benefit from PR with exercise as a critical intervention.
dc.description.funderDepartment of Health Sciences
dc.description.funderPontificia Universidad Católica de Chile
dc.fechaingreso.objetodigital2024-01-22
dc.fuente.origenScopus
dc.identifier.doi10.3390/biology11101446
dc.identifier.eissn2079-97737
dc.identifier.issn2079-7737
dc.identifier.scopusidSCOPUS_ID:85140371603
dc.identifier.urihttps://doi.org/10.3390/biology11101446
dc.identifier.urihttps://www.mdpi.com/2079-7737/11/10/1446
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80903
dc.identifier.wosidWOS:000872183400001
dc.information.autorucEscuela de Medicina; Contreras Briceno, Felipe; 0000-0002-0674-7506; 1011730
dc.information.autorucEscuela de Medicina; Espinosa Ramírez, Maximiliano Andrés; 0000-0002-0840-1904; 215830
dc.issue.numero10
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final1501
dc.pagina.inicio1443
dc.publisherMDPI
dc.relation.ispartofBiology
dc.revistaBiology
dc.rightsacceso abierto
dc.subjectExercise
dc.subjectPhysical activity
dc.subjectPost-COVID-19
dc.subjectRehabilitation
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEccentric Training in Pulmonary Rehabilitation of Post-COVID-19 Patients: An Alternative for Improving the Functional Capacity, Inflammation, and Oxidative Stress
dc.typeartículo
dc.volumen11
sipa.codpersvinculados1011730
sipa.codpersvinculados215830
sipa.trazabilidadSCOPUS;10-11-2022
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