Effectiveness of the implementation of a re-linkage to care strategy in patients with Hepatitis C who were lost of follow-up

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dc.catalogadorpau
dc.contributor.authorMendizabal, Manuel
dc.contributor.authorThompson, Marcos Andres
dc.contributor.authorRidruejo, Ezequiel
dc.contributor.authorGonzalez Ballerga, Esteban
dc.contributor.authorRuiz Velasco, Jose Antonio Velarde
dc.contributor.authorPalazzo, Ana
dc.contributor.authorMezzano, Gabriel
dc.contributor.authorMuñoz Espinosa, Linda Elsa
dc.contributor.authorPessoa, Mario
dc.contributor.authorCerda Reyes, Eira
dc.contributor.authorSoza, Alejandro
dc.contributor.authorRuiz, Sandro
dc.contributor.authorGomez-Aldana, Andres Jose
dc.contributor.authorGerona, Solange
dc.contributor.authorFuster, Francisco
dc.contributor.authorAnders, Margarita
dc.contributor.authorBeltran Valdivia, Flor De Maria
dc.contributor.authorPoniachik, Jaime
dc.contributor.authorSchinoni, Maria Isabel
dc.contributor.authorHernandez, Nelia
dc.contributor.authorMontes, Pedro
dc.contributor.authorGirala, Marcos
dc.contributor.authorCastillo, Lida
dc.contributor.authorCastillo-Barradas, Mauricio
dc.contributor.authorChavez, Rocio
dc.contributor.authorCabrera, Cecilia
dc.contributor.authorTenorio, Laura
dc.contributor.authorZevallos, Katherine
dc.contributor.authorGaravito, Jorge
dc.contributor.authorBrutti, Julia
dc.contributor.authorTagle, Martin
dc.contributor.authorCastro Narro, Graciela
dc.contributor.authorVera Pozo, Emilia
dc.contributor.authorPerazzo, Rosalia
dc.contributor.authorGuillermo Toro, Luis
dc.contributor.authorVaron, Adriana
dc.contributor.authorFerreiro, Melina
dc.contributor.authorLazcano, Monserrat
dc.contributor.authorDolores Murga, Maria
dc.contributor.authorGomez, Fernando
dc.contributor.authorHernandez, Larissa
dc.contributor.authorDamasio Moutinho, Bruna
dc.contributor.authorGandara-Calderon, Julian
dc.contributor.authorVargas Domínguez, José Ignacio
dc.contributor.authorSimian, Daniela
dc.contributor.authorSilva, Marcelo
dc.date.accessioned2023-05-18T19:49:45Z
dc.date.available2023-05-18T19:49:45Z
dc.date.issued2021
dc.description.abstractBackground: In order to achieve the World Health Organization’s ambitious goal of eliminating hepatitis C (HCV), we must implement innovative strategies to diagnose and treat more patients. Therefore, our study aimed to identify patients with chronic HCV infection who lost follow-up and offer them re-linkage to care and treatment with direct-acting antivirals (DAAs). Methods: We conducted an implementation study of a strategy to contact patients with chronic HCV who were not under regular follow-up in 10 countries from Latin America. Patients with HCV were identified by the international classification of diseases (ICD-9/10) or similar. Medical records were then reviewed to confirm the diagnosis of chronic HCV infection defined as anti-HCV + and detectable HCVRNA. Identified patients who were not under follow-up by a liver specialist were contacted to offer them a medical reevaluation and, eventually, treatment with DAA. Results: A total of 3,709 patients were classified as HCV, of which 367 (9.9%) presented undetectable HCVRNA, and 148 (4.0%) were wrongly coded. Overall, 3,194 (86.1%) individuals were identified with chronic HCV infection, 49,9% were male, median age was 61 years (IQR 51-69); 166 (5.2%) developed hepatocellular carcinoma, and 117 (3.7%) underwent liver transplantation. Advanced liver fibrosis (F3-F4) was present in 1,361 (42.6%) patients. A total of 1,764 (55.2%) patients were under close care. Of these, 1,371 (74.7%) received antiviral treatment, 70 (5.3%) did not achieve sustained virologic response, 314 (17.8%) were not treated for different reasons and 133 (7.5%) died. We identified 1,430 (44.8%) patients who were lost of follow-up, 564 (39.4%) of whom were finally located. Of those contacted, 402 (71.3%) were candidates to receive DAAs, 108 (19.2%) were treated in other institutions, 12 (2.1%) did not wish to be treated, and 42 (7.4%) died (Figure). Globally, in our study 786/3,194 (24.6%) patients were candidates to receive antiviral therapies. Conclusion: In our cohort, 1 out of 4 patients with chronic HCV could be re-linked to care and treated. This strategy impresses to be effective, accessible and, significantly impact on the HCV cascade to cure.
dc.format.extent2
dc.fuente.origenORCID
dc.identifier.doi10.1002/hep.32188
dc.identifier.issn0270-9139
dc.identifier.urihttps://publons.com/wos-op/publon/52857649/
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/67111
dc.information.autorucEscuela de Medicina ; Soza, Alejandro ; 0000-0002-1136-9554 ; 461
dc.information.autorucEscuela de Medicina ; Vargas Domínguez, José Ignacio ; 0000-0002-1547-2292 ; 120713
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final585A
dc.pagina.inicio584A
dc.relation.ispartofThe Liver Meeting (AASLD) (61° ; 2021)
dc.revistaHepatology
dc.rightsacceso restringido
dc.titleEffectiveness of the implementation of a re-linkage to care strategy in patients with Hepatitis C who were lost of follow-up
dc.typecomunicación de congreso
dc.volumen74
sipa.codpersvinculados461
sipa.codpersvinculados120713
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