Trypanosoma cruzi: In vitro effect of aspirin with nifurtimox and benznidazole

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dc.contributor.authorLopez Munoz, Rodrigo
dc.contributor.authorFaundez, Mario
dc.contributor.authorKlein, Sebastian
dc.contributor.authorEscanilla, Sebastian
dc.contributor.authorTorres, Gloria
dc.contributor.authorLee Liu, Dasfne
dc.contributor.authorFerreira, Jorge
dc.contributor.authorKemmerling, Ulrike
dc.contributor.authorOrellana, Myriam
dc.contributor.authorMorello, Antonio
dc.contributor.authorFerreira, Arturo
dc.contributor.authorMaya, Juan D.
dc.date.accessioned2024-01-10T13:09:51Z
dc.date.available2024-01-10T13:09:51Z
dc.date.issued2010
dc.description.abstractNifurtimox and benznidazole are the only active drugs against Trypanosoma cruzi; however, they have limited efficacy and severe side effects. During primoinfection, T cruzi infected macrophages mount an antiparasitic response, which the parasite evades through an increase of tumor growth factor beta and PGE(2) activation as well as decreased iNOS activity. Thus, prostaglandin synthesis inhibition with aspirin might increase macrophage antiparasitic activity and increase nifurtimox and benznidazole effect.
dc.description.abstractAspirin alone demonstrated a low effect upon macrophage antiparasitic activity. However, isobolographic analysis of the combined effects of aspirin, nifurtimox and benznidazole indicated a synergistic effect on T cruzi infection of RAW cells, with combinatory indexes of 0.71 and 0.61, respectively.
dc.description.abstractThe observed effect of aspirin upon T cruzi infection was not related with the PGE(2) synthesis inhibition. Nevertheless, NO- levels were restored by aspirin in T. cruzi-infected RAW cells, contributing to macrophage antiparasitic activity improvement.
dc.description.abstractThus, the synergy of aspirin with nifurtimox and benznidazole is due to the capability of aspirin to increase antiparasitic activity of macrophages. (C) 2009 Elsevier Inc. All rights reserved.
dc.fechaingreso.objetodigital22-03-2024
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.exppara.2009.09.005
dc.identifier.eissn1090-2449
dc.identifier.issn0014-4894
dc.identifier.pubmedidMEDLINE:19735656
dc.identifier.urihttps://doi.org/10.1016/j.exppara.2009.09.005
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77685
dc.identifier.wosidWOS:000273884300004
dc.information.autorucQuímica;Escanilla S;S/I;132286
dc.information.autorucQuímica;Faúndez M;S/I;174901
dc.information.autorucQuímica;Klein S;S/I;136021
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final171
dc.pagina.inicio167
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.revistaEXPERIMENTAL PARASITOLOGY
dc.rightsacceso restringido
dc.subjectTrypanosoma cruzi
dc.subjectAspirin
dc.subjectNifurtimox
dc.subjectBenznidazole
dc.subjectSynergism
dc.subjectGROWTH-FACTOR-BETA
dc.subjectAPOPTOTIC CELLS
dc.subjectACUTE-PHASE
dc.subjectINFECTION
dc.subjectMACROPHAGES
dc.subjectPROSTAGLANDIN
dc.subjectPROLIFERATION
dc.subjectMETABOLISM
dc.subjectSYNERGISM
dc.subjectTOXICITY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTrypanosoma cruzi: In vitro effect of aspirin with nifurtimox and benznidazole
dc.typeartículo
dc.volumen124
sipa.codpersvinculados132286
sipa.codpersvinculados174901
sipa.codpersvinculados136021
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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