Differential Severe Acute Respiratory Syndrome Coronavirus 2-Specific Humoral Response in Inactivated Virus-Vaccinated, Convalescent, and Breakthrough-Infected Subjects

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dc.article.number320
dc.catalogadorgrr
dc.contributor.authorDuarte Peñaloza, Luisa Fernanda
dc.contributor.authorVazquez Hernandez Yaneisi
dc.contributor.authorDiethelm Varela, Benjamin Manuel
dc.contributor.authorPavez, Valentina
dc.contributor.authorBerrios-Rojas, Roslye
dc.contributor.authorRiedel, Claudia A.
dc.contributor.authorMendez, Constanza
dc.contributor.authorWhite, Jessica A.
dc.contributor.authorKalergis Parra, Alexis Mikes
dc.contributor.authorBueno Ramírez, Susan Marcela
dc.contributor.authorGonzález Muñoz, Pablo Alberto
dc.date.accessioned2023-09-28T18:54:30Z
dc.date.available2023-09-28T18:54:30Z
dc.date.issued2023
dc.description.abstractBackground. We sought to identify potential antigens for discerning between humoral responses elicited after vaccination with CoronaVac (a severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] inactivated vaccine), natural infection, or breakthrough infection., Methods. Serum samples obtained from volunteers immunized with CoronaVac (2 and 3 doses), breakthrough case patients, and from convalescent individuals were analyzed to determine the immunoglobulin (Ig) G responses against 3 structural and 8 nonstructural SARS-CoV-2 antigens., Results. Immunization with CoronaVac induced higher levels of antibodies against the viral membrane (M) protein compared with convalescent subjects both after primary vaccination and after a booster dose. Individuals receiving a booster dose displayed equivalent levels of IgG antibodies against the nucleocapsid (N) protein, similar to convalescent subjects. Breakthrough case patients produced the highest antibody levels against the N and M proteins. Antibodies against nonstructural viral proteins were present in >50% of the convalescent subjects., Conclusions. Vaccinated individuals elicited a different humoral response compared to convalescent subjects. The analysis of particular SARS-CoV-2 antigens could be used as biomarkers for determining infection in subjects previously vaccinated with CoronaVac.
dc.fechaingreso.objetodigital2023-09-28
dc.fuente.origenWOS
dc.identifier.doi10.1093/infdis/jiad320
dc.identifier.eissn1537-6613
dc.identifier.issn0022-1899
dc.identifier.pubmedid37572355
dc.identifier.urihttps://doi.org/10.1093/infdis/jiad320
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74741
dc.identifier.wosidWOS:001054553300001
dc.information.autorucFacultad de Ciencias Biológicas; Duarte Peñaloza, Luisa Fernanda; 0000-0003-1828-1800; 1031205
dc.information.autorucFacultad de Ciencias Biológicas; Vazquez Hernandez Yaneisi; S/I; 1025308
dc.information.autorucFacultad de Ciencias Biológicas; Diethelm Varela, Benjamin Manuel; 0000-0002-5465-6924; 217234
dc.information.autorucFacultad de Ciencias Biológicas; Berrios Rojas, Roslye; 0000-0002-6949-9829; S/I
dc.information.autorucFacultad de Ciencias Biológicas; Méndez, Constanza; 0000-0002-1509-4471; S/I
dc.information.autorucFacultad de Ciencias Biológicas; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan Marcela; 0000-0002-7551-8088; 113541
dc.information.autorucFacultad de Ciencias Biológicas; González Muñoz, Pablo Alberto; 0000-0001-7709-6870; 15616
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final11
dc.pagina.inicio1
dc.publisherOXFORD UNIV PRESS INC
dc.revistaJOURNAL OF INFECTIOUS DISEASES
dc.rightsacceso abierto
dc.subjectSARS-CoV-2
dc.subjectAntibody responses
dc.subjectBreakthrough
dc.subjectCoronaVac
dc.subjectVaccination
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDifferential Severe Acute Respiratory Syndrome Coronavirus 2-Specific Humoral Response in Inactivated Virus-Vaccinated, Convalescent, and Breakthrough-Infected Subjects
dc.typeartículo
sipa.codpersvinculados1031205
sipa.codpersvinculados1025308
sipa.codpersvinculados217234
sipa.codpersvinculados90610
sipa.codpersvinculados113541
sipa.codpersvinculados15616
sipa.indexWOS
sipa.trazabilidadWOS;2023-09-23
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