Ondansetron and droperidol in the prevention of postoperative nausea and vomiting

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dc.catalogadoraba
dc.contributor.authorBugedo Tarraza, Guillermo
dc.contributor.authorGonzález Sotomayor, Julio
dc.contributor.authorAsenjo, C.
dc.contributor.authorCuadra F., Juan Carlos de la
dc.contributor.authorGajardo, A.
dc.contributor.authorCastillo Fuenzalida, Luis
dc.contributor.authorMuñoz L., Hernán
dc.contributor.authorDagnino Sepúlveda, Jorge
dc.date.accessioned2024-03-21T19:51:28Z
dc.date.available2024-03-21T19:51:28Z
dc.date.issued1999
dc.description.abstractWe have performed a prospective, randomized, double-blind clinical study to assess the efficacy of ondansetron, droperidol, or both, in preventing postoperative emesis. We studied 242 patients undergoing biliary or gynaecological surgery under general anaesthesia. Shortly before induction of anaesthesia, patients received: saline i.v. (group 1, n=62); droperidol 2.5 mg i.v. (group 2, n=60); ondansetron 4 mg i.v. (group 3, n=57); or droperidol 2.5 mg with ondansetron 4 mg i.v. (group 4, n=63). Nausea occurred in 45%, 37%, 32% and 29% (P=0.234) and vomiting in 23%, 17%, 9% and 5% (P=0.016) of patients in groups 1, 2, 3 and 4, respectively, during the first 24 h. Groups 2 and 4 had greater sedation scores than group 1 during the first 3 h (P<0.01). We conclude that both droperidol and ondansetron showed a significant antiemetic effect, ondansetron was not significantly better than droperidol, and the combination of droperidol and ondansetron was better than droperidol but no better than ondansetron alone.
dc.fechaingreso.objetodigital2024-03-21
dc.format.extent2
dc.fuente.origenWOS
dc.identifier.doi10.1093/bja/83.5.813
dc.identifier.eissn1471-6771
dc.identifier.issn0007-0912
dc.identifier.pubmedidMEDLINE:10690150
dc.identifier.urihttps://doi.org/10.1093/bja/83.5.813
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/84676
dc.identifier.wosidWOS:000084017000024
dc.information.autorucEscuela de Medicina; Bugedo Tarraza, Guillermo; 0000-0001-7527-6202; 60490
dc.information.autorucEscuela de Medicina; González Sotomayor, Julio; 0000-0002-4184-490X; 81189
dc.information.autorucEscuela de Medicina; Cuadra F., Juan Carlos de la; 0000-0002-3868-0764; 58562
dc.information.autorucEscuela de Medicina; Castillo Fuenzalida, Luis; S/I; 54397
dc.information.autorucEscuela de Medicina; Muñoz L., Hernán; S/I; 73573
dc.information.autorucEscuela de Medicina; Dagnino Sepúlveda, Jorge; 0000-0001-5536-9786; 29778
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final814
dc.pagina.inicio813
dc.revistaBritish Journal of Anaesthesia
dc.rightsacceso abierto
dc.subjectVomiting, incidence
dc.subjectVomiting, nausea
dc.subjectVomiting, antiemetics
dc.subjectPharmacology, droperidol
dc.subjectParmacology, ondansetron
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleOndansetron and droperidol in the prevention of postoperative nausea and vomiting
dc.typeartículo
dc.volumen83
sipa.codpersvinculados60490
sipa.codpersvinculados81189
sipa.codpersvinculados58562
sipa.codpersvinculados54397
sipa.codpersvinculados73573
sipa.codpersvinculados29778
sipa.trazabilidadWOS;05-06-2021
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