Lung aeration estimated by chest electrical impedance tomography and lung ultrasound during extubation

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dc.article.number91
dc.catalogadoryvc
dc.contributor.authorJoussellin, Vincent
dc.contributor.authorBonny, Vincent
dc.contributor.authorSpadaro, Savino
dc.contributor.authorClerc, Sébastien
dc.contributor.authorParfait, Mélodie
dc.contributor.authorFerioli, Martina
dc.contributor.authorSieye, Antonin
dc.contributor.authorJalil Contreras, Yorschua Frederick
dc.contributor.authorJaniak, Vincent
dc.contributor.authorPinna, Andrea
dc.contributor.authorDres, Martin
dc.date.accessioned2023-10-24T14:31:24Z
dc.date.available2023-10-24T14:31:24Z
dc.date.issued2023
dc.date.updated2023-10-01T00:03:01Z
dc.description.abstractAbstract: Background: This study hypothesized that patients with extubation failure exhibit a loss of lung aeration and heterogeneity in air distribution, which could be monitored by chest EIT and lung ultrasound. Patients at risk of extubation failure were included after a successful spontaneous breathing trial. Lung ultrasound [with calculation of lung ultrasound score (LUS)] and chest EIT [with calculation of the global inhomogeneity index, frontback center of ventilation (CoV), regional ventilation delay (RVD) and surface available for ventilation] were performed before extubation during pressure support ventilation (H0) and two hours after extubation during spontaneous breathing (H2). EIT was then repeated 6 h (H6) after extubation. EIT derived indices and LUS were compared between patients successfully extubated and patients with extubation failure. Results: 40 patients were included, of whom 12 (30%) failed extubation. Before extubation, when compared with patients with successful extubation, patients who failed extubation had a higher LUS (19 vs 10, p = 0.003) and a smaller surface available for ventilation (352 vs 406 pixels, p = 0.042). After extubation, GI index and LUS were higher in the extubation failure group, whereas the surface available for ventilation was lower. The RVD and the CoV were not different between groups. Conclusion: Before extubation, a loss of lung aeration was observed in patients who developed extubation failure afterwards. After extubation, this loss of lung aeration persisted and was associated with regional lung ventilation heterogeneity. Trial registration Clinical trials, NCT04180410, Registered 27 November 2019—prospectively registered. https://clinicaltrials.gov/ct2/show/NCT04180410
dc.fuente.origenAutoarchivo
dc.identifier.urihttps://doi.org/10.1186/s13613-023-01180-3
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75168
dc.information.autorucEscuela de Medicina ; Jalil Contreras, Yorschua Frederick ; S/I ; 1079709
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final12
dc.pagina.inicio1
dc.revistaAnnals of Intensive Care
dc.rightsacceso abierto
dc.rights.holderLa Société de Réanimation de Langue Francaise = The French Society of Intensive Care (SRLF)
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectElectrical impedance tomography
dc.subjectLung ultrasound
dc.subjectMechanical ventilation
dc.subjectExtubation failure
dc.subjectWeaning
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLung aeration estimated by chest electrical impedance tomography and lung ultrasound during extubation
dc.typeartículo
dc.volumen13
sipa.codpersvinculados1079709
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