Pharmacokinetics of levobupivacaine (2.5 mg/kg) after caudal administration in children younger than 3 years

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dc.contributor.authorCortinez, Luis I.
dc.contributor.authorFuentes, Ricardo
dc.contributor.authorSolari, Sandra
dc.contributor.authorOstermann, Paola
dc.contributor.authorVega, Miguel
dc.contributor.authorMunoz, Hernan R.
dc.date.accessioned2024-01-10T12:07:30Z
dc.date.available2024-01-10T12:07:30Z
dc.date.issued2008
dc.description.abstractBACKGROUND: Caudal administration of levobupivacaine (2.5 mg/kg) in children is used frequently in some hospitals. However, no reports of levobupivacaine concentrations have been published with this dosing scheme. We report the results of a study on the pharmacokinetics of levobupivacaine (2.5 mg/kg) after caudal administration in children younger than 3 yr.
dc.description.abstractMETHODS: Ten children, aged 1-36 mo and scheduled for subumbilical surgery were studied under sevoflurane anesthesia. After caudal injection of 0.25% levobupivacaine (2.5 mg/kg), serial venous blood samples were taken for 3 h to measure total plasma concentration levels of levobupivacaine. Median (range) levobupivacaine C-max and T-max measured were 1.48 (0.62-2.40) mu g/mL and 37 (10-60) min. The highest individual C-max was observed in a 1-mo-old infant 30 min after caudal block.
dc.description.abstractCONCLUSIONS: The highest C-max reached in this study was close to the toxic threshold of adult patients. Although no adverse events have been reported, care must be taken, especially in small infants, after caudal administration of levobupivacaine (2.5 mg/kg).
dc.fechaingreso.objetodigital2024-05-14
dc.format.extent3 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1213/ane.0b013e318181bb4d
dc.identifier.issn0003-2999
dc.identifier.pubmedidMEDLINE:18806025
dc.identifier.urihttps://doi.org/10.1213/ane.0b013e318181bb4d
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76292
dc.identifier.wosidWOS:000259522100019
dc.information.autorucMedicina;Cortínez L;S/I;79356
dc.information.autorucMedicina;Fuentes R;S/I;91662
dc.information.autorucMedicina;Muñoz H;S/I;73573
dc.information.autorucMedicina;Solari S;S/I;1871
dc.issue.numero4
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final1184
dc.pagina.inicio1182
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaANESTHESIA AND ANALGESIA
dc.rightsregistro bibliográfico
dc.subjectAGE
dc.subject0.25-PERCENT
dc.subjectINFANTS
dc.titlePharmacokinetics of levobupivacaine (2.5 mg/kg) after caudal administration in children younger than 3 years
dc.typeartículo
dc.volumen107
sipa.codpersvinculados79356
sipa.codpersvinculados91662
sipa.codpersvinculados73573
sipa.codpersvinculados1871
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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