Mineralocorticoid receptor modulation by dietary sodium influences NAFLD development in mice

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dc.catalogadorvzp
dc.contributor.authorCabrera, Daniel
dc.contributor.authorRao, Isabel
dc.contributor.authorRaasch, Fabiola
dc.contributor.authorSolis, Nancy
dc.contributor.authorPizarro, Margarita
dc.contributor.authorFreire, Mariela
dc.contributor.authorDe Urturi, Diego Saenz
dc.contributor.authorRamirez, Carolina A.
dc.contributor.authorTriantafilo, Nicolas
dc.contributor.authorLeon, Jonathan
dc.contributor.authorRiquelme, Arnoldo
dc.contributor.authorBarrera, Francisco
dc.contributor.authorBaudrand, Rene
dc.contributor.authorAspichueta, Patricia
dc.contributor.authorArrese, Marco
dc.contributor.authorArab, Juan P.
dc.date.accessioned2024-05-31T13:40:24Z
dc.date.available2024-05-31T13:40:24Z
dc.date.issued2021
dc.description.abstractIntroduction and Objectives: Nonalcoholic-fatty-liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome (MetS). Mineralocorticoid receptor (MR) activation is associated with increased risk of MetS but few studies have assessed the role of liver MR on NAFLD. We aimed to evaluate the effect of MR modulation by sodium intake in liver injury in experimental models of NAFLD.
dc.description.abstractMaterials and Methods: C57BL/6J mice were fed either a high-fat-diet (HFD) or a choline/methionine deficient (MCD) diet with different sodium concentrations. Hepatic concentration of lipid species, serum aldosterone levels, expression of MR, proinflammatory and profibrotic markers and liver histology were assessed.
dc.description.abstractResults: Mice fed with High-Na+/HFD showed a lower MR expression in liver (p = 0.01) and less steatosis on histology (p = 0.04). Consistently, animals from this group exhibited lower levels of serum aldosterone (p = 0.028) and lower hepatic triglyceride content (p = 0.008). This associated to a reduced expression of lipogenic genes, significant changes in lipid subspecies, lower HOMA-IR (p < 0.05), and lower expression of pro-inflammatory and profibrotic markers compared to those mice fed a Low-Na+/HFD. Additionally, mice fed a High-Na+/HFD showed higher expression of salt-inducible kinase (SIK)-1 and lower expression of serum-and-glucocorticoid-inducible kinase (SGK)-1. Similar results were observed with the MCD diet model.
dc.description.abstractConclusion: We identified in two experimental models of NAFLD that High-Na+ diet content is associated to lower serum aldosterone levels and hepatic MR downregulation, associated to decreased steatosis and reduced de novo hepatic lipogenesis, proinflammatory and profibrotic markers. Decreased activation of hepatic MR seems to generate beneficial downstream inhibition of lipogenesis in experimental NAFLD. (C) 2021 Fundacion Clinica Medica Sur, A.C. Published by Elsevier Espa?a, S.L.U.
dc.fechaingreso.objetodigital2024-06-03
dc.format.extent10 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.aohep.2021.100357
dc.identifier.issn1665-2681
dc.identifier.urihttps://doi.org/10.1016/j.aohep.2021.100357
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86157
dc.identifier.wosidWOS:000696803000010
dc.information.autorucEscuela de Medicina; Baudrand Biggs, Rene Felipe; 0000-0002-8655-4957; 1025
dc.issue.numero100357
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final10
dc.pagina.inicio1
dc.publisherELSEVIER ESPANA
dc.revistaAnnals of Hepatology
dc.rightsacceso abierto
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subjectNon-alcoholic fatty liver disease
dc.subjectNAFLD
dc.subjectNASH
dc.subjectSteatohepatitis
dc.subjectFatty liver
dc.subjectMineralocorticoid receptor
dc.subjectSodium
dc.subjectLiver injury
dc.subjectSALT-INDUCIBLE KINASE
dc.subjectFATTY LIVER-DISEASE
dc.subjectFIBROSIS
dc.subjectMODEL
dc.subjectEXPRESSION
dc.subjectFRUCTOSE
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleMineralocorticoid receptor modulation by dietary sodium influences NAFLD development in mice
dc.typeartículo
dc.volumen24
sipa.codpersvinculados1024
sipa.trazabilidadORCID;2024-05-27
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