Glycoprotein Ib/IX complex is the target in rifampicin-induced immune thrombocytopenia

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dc.contributor.authorPereira, J
dc.contributor.authorHidalgo, P
dc.contributor.authorOcqueteau, M
dc.contributor.authorBlacutt, M
dc.contributor.authorMarchesse, M
dc.contributor.authorNien, Y
dc.contributor.authorLetelier, L
dc.contributor.authorMezzano, D
dc.date.accessioned2024-01-10T12:39:15Z
dc.date.available2024-01-10T12:39:15Z
dc.date.issued2000
dc.description.abstractThrombocytopenia is a major adverse effect of several drug treatments. Rifampicin has been recognized as a cause of immune thrombocytopenia during intermittent high-dose therapy. We characterized the antibody of a patient who presented with purpura and thrombocytopenia during treatment of tuberculosis with rifampicin. Drug-dependent binding of the antibody to platelets was demonstrated by flow cytometry. In a glycoprotein-specific immunoassay, the binding epitope of the IgG antibody was found in the glycoprotein Ib/IX complex, using four different monoclonal antibodies (mAbs) against various epitopes on the GPIb/IX complex, as well as mAbs against GPIIb/IIIa, GPIa/IIa and GPIV. By immunoprecipitation of biotin-labelled platelets, reactivity of the antibody with GPIb/IX was found only in the presence of the drug. These findings clearly demonstrate that rifampicin induces the formation of drug-dependent antibodies capable of causing thrombocytopenia. The binding site of the rifampicin-dependent antibody, located in the GPIb/IX complex, seems to be a favoured target for antibodies induced by different drugs.
dc.fechaingreso.objetodigital2024-05-07
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1046/j.1365-2141.2000.02299.x
dc.identifier.issn0007-1048
dc.identifier.pubmedidMEDLINE:11054081
dc.identifier.urihttps://doi.org/10.1046/j.1365-2141.2000.02299.x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77167
dc.identifier.wosidWOS:000089857800026
dc.information.autorucMedicina;Mezzano D;S/I;99455
dc.information.autorucMedicina;Ocqueteau M;S/I;71377
dc.information.autorucMedicina;Pereira J;S/I;99371
dc.issue.numero4
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final910
dc.pagina.inicio907
dc.publisherBLACKWELL SCIENCE LTD
dc.revistaBRITISH JOURNAL OF HAEMATOLOGY
dc.rightsregistro bibliográfico
dc.subjectthrombocytopenia
dc.subjectimmune-mediated
dc.subjectdrug-dependent
dc.subjectdrug-induced
dc.subjectglycoprotein Ib/IX
dc.subjectMONOCLONAL-ANTIBODY
dc.subjectIB-IX
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGlycoprotein Ib/IX complex is the target in rifampicin-induced immune thrombocytopenia
dc.typeartículo
dc.volumen110
sipa.codpersvinculados99455
sipa.codpersvinculados71377
sipa.codpersvinculados99371
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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