Florid reactive lymphoid hyperplasia (lymphoma-like lesion) of the uterine cervix

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dc.contributor.authorRamalingam, Preetha
dc.contributor.authorZoroquiain, Pablo
dc.contributor.authorValbuena, Jose R.
dc.contributor.authorKemp, Bonnie L.
dc.contributor.authorMedeiros, L. Jeffrey
dc.date.accessioned2024-01-10T13:48:29Z
dc.date.available2024-01-10T13:48:29Z
dc.date.issued2012
dc.description.abstractLymphoma-like lesion (LLL) of the female genital tract is an older term in the literature that describes a florid reactive lymphoid proliferation that can be misinterpreted as lymphoma. Multiple causes of LLL have been suggested but most cases remain unexplained. We describe the clinicopathologic features of 6 patients with LLL involving the uterine cervix. Five patients presented with abnormal Papanicolaou test (Pap smear), and 3 patients had a biopsy procedure performed prior to detection of LLL in a loop electrosurgical excision procedure (LEEP). In each specimen, surface epithelial erosion was associated with a superficial, polymorphous lymphoid infiltrate with numerous scattered large cells, without cellular necrosis or sclerosis. Squamous dysplasia was present in 4 patients. Immunohistochemical studies revealed a mixed population of Band T-lymphoid cells. T-cells were more numerous but B-cells and formed aggregates or sheets in areas. The large cells were predominantly B-cells positive for CD20 and negative for CD3 in all cases. CD30 was positive 3 cases, and Epstein-Barr virus-encoded RNA was positive in 3 cases. Assessment for clonality in 1 patient using polymerase chain reaction (PCR) methods revealed monoclonal immunoglobulin heavy chain (IgH) gene rearrangements. At last clinical follow-up there was no evidence of progressive or systemic disease. We conclude that LLL of the cervix has a number of etiologies and that a prior surgical procedure, present in 3 patients in this study, is another possible etiology. As has been reported by others, monoclonal IgH gene rearrangements can be detected in this entity which has a benign clinical course. (C) 2012 Elsevier Inc. All rights reserved.
dc.fechaingreso.objetodigital2024-03-19
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.anndiagpath.2011.08.004
dc.identifier.issn1092-9134
dc.identifier.pubmedidMEDLINE:22056039
dc.identifier.urihttps://doi.org/10.1016/j.anndiagpath.2011.08.004
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79369
dc.identifier.wosidWOS:000299586400005
dc.information.autorucMedicina;Valbuena J;S/I;1004186
dc.information.autorucMedicina;Zoroquiain P;S/I;175130
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final28
dc.pagina.inicio21
dc.publisherELSEVIER SCIENCE INC
dc.revistaANNALS OF DIAGNOSTIC PATHOLOGY
dc.rightsacceso restringido
dc.subjectLymphoma-like lesion
dc.subjectCervix
dc.subjectIgH
dc.subjectPolymerase Chain Reaction (PCR)
dc.subjectPapanicolaou test (Pap smear)
dc.subjectFEMALE GENITAL-TRACT
dc.subjectCELL LYMPHOMA
dc.subjectDISORDERS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFlorid reactive lymphoid hyperplasia (lymphoma-like lesion) of the uterine cervix
dc.typeartículo
dc.volumen16
sipa.codpersvinculados1004186
sipa.codpersvinculados175130
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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