Down's syndrome is a risk factor for severe lower respiratory tract infection due to respiratory syncytial virus

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dc.contributor.authorGalleguillos, C.
dc.contributor.authorGalleguillos, B.
dc.contributor.authorLarios, G.
dc.contributor.authorMenchaca, G.
dc.contributor.authorBont, L.
dc.contributor.authorCastro-Rodriguez, J. A.
dc.date.accessioned2020-01-14T01:51:56Z
dc.date.available2020-01-14T01:51:56Z
dc.date.issued2016
dc.description.abstractAim Previous studies have suggested that Down's syndrome is an independent risk factor for severe respiratory infection due to respiratory syncytial virus (RSV). We compared the clinical characteristics of children with and without Down's syndrome hospitalised due to RSV. Methods This retrospective cohort study compared data from hospitalisations due to RSV lower respiratory tract infections (LRTI) in children under 14 years of age with (n = 58) and without (n = 58) Down's syndrome. Results The Down's group had longer hospital stays than the controls of six versus four days (p < 0.0001), even after adjusting for age, weeks of gestation at birth, presence of asthma, bronchopulmonary dysplasia, haemodynamically significant and nonsignificant congenital heart disease. This difference increased when only children under one year of age were analysed to 11 versus five days (p < 0.0001). Children with Down's syndrome were more likely to be admitted to intensive care unit (43.1% versus 22.4%, p = 0.017), need noninvasive mechanical ventilation (36.2% versus 13.7%, p = 0.005) and be prescribed antibiotics and steroids. Conclusion Children with Down's syndrome hospitalised due to RSV LRTI had longer hospital stays and worse clinical courses than controls, highlighting the need for RSV prophylaxis for children with Down's syndrome, especially under one year of age.Aim Previous studies have suggested that Down's syndrome is an independent risk factor for severe respiratory infection due to respiratory syncytial virus (RSV). We compared the clinical characteristics of children with and without Down's syndrome hospitalised due to RSV. Methods This retrospective cohort study compared data from hospitalisations due to RSV lower respiratory tract infections (LRTI) in children under 14 years of age with (n = 58) and without (n = 58) Down's syndrome. Results The Down's group had longer hospital stays than the controls of six versus four days (p < 0.0001), even after adjusting for age, weeks of gestation at birth, presence of asthma, bronchopulmonary dysplasia, haemodynamically significant and nonsignificant congenital heart disease. This difference increased when only children under one year of age were analysed to 11 versus five days (p < 0.0001). Children with Down's syndrome were more likely to be admitted to intensive care unit (43.1% versus 22.4%, p = 0.017), need noninvasive mechanical ventilation (36.2% versus 13.7%, p = 0.005) and be prescribed antibiotics and steroids. Conclusion Children with Down's syndrome hospitalised due to RSV LRTI had longer hospital stays and worse clinical courses than controls, highlighting the need for RSV prophylaxis for children with Down's syndrome, especially under one year of age.
dc.fuente.origenFacultad de Medicina
dc.identifier.doi10.1111/apa.13552
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/27521
dc.issue.numeroNo. 11
dc.revistaActa Paediatrica, International Journal of Paediatricses_ES
dc.rightsacceso restringido
dc.subjectCongenital heart diseasees_ES
dc.subjectDown's syndromees_ES
dc.subjectPalivizumabes_ES
dc.subjectRespiratory syncytial viruses_ES
dc.subjectRisk factorses_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleDown's syndrome is a risk factor for severe lower respiratory tract infection due to respiratory syncytial viruses_ES
dc.typeartículo
dc.volumenVol. 105
sipa.codpersvinculados126390
sipa.codpersvinculados69308
sipa.codpersvinculados113247
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