Altered Chemokine Receptor Expression in Papillary Thyroid Cancer

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dc.contributor.authorGonzalez, Hernan E.
dc.contributor.authorLeiva, Andrea
dc.contributor.authorTobar, Hugo
dc.contributor.authorBoehmwald, Karen
dc.contributor.authorTapia, Grace
dc.contributor.authorTorres, Javiera
dc.contributor.authorMosso, Lorena M.
dc.contributor.authorBueno, Susan M.
dc.contributor.authorGonzalez, Pablo
dc.contributor.authorKalergis, Alexis M.
dc.contributor.authorRiedel, Claudia A.
dc.date.accessioned2024-01-10T12:04:10Z
dc.date.available2024-01-10T12:04:10Z
dc.date.issued2009
dc.description.abstractBackground: Papillary thyroid cancer (PTC), the most prevalent type of differentiated thyroid carcinoma, displays a strikingly high frequency of lymph node metastasis (LNM). Recent data suggest that chemokines can play an important role in promoting tumor progression and metastatic migration of tumor cells. Here we have evaluated whether PTC tissues express a different pattern of chemokine receptors and if the expression of these receptors correlates with LNM.
dc.description.abstractMethods: We assessed by immunohistochemistry and flow cytometry the expression of the chemokine receptors CCR3, CCR7, and CXCR4 in tumor and nonmalignant thyroid tissues from patients suffering from PTC. Expression of these receptors in PTC was correlated with the clinical pathological condition of PTC.
dc.description.abstractResults: Our data show a significant enhancement of CCR3 (2.5 times higher, p = 0.038) and CXCR4 (1.7 times higher, p = 0.02) expression in PTC tissues as determined by immunohistochemical staining, and of CCR3 (3.5 times higher, p < 0.002) in the plasma membrane as determined by flow cytometric analyses, compared to controls. In addition, while CCR3 (100%) and CXCR4 (90%) were present in both tumor and control thyroid tissues, expression of CCR7 was scarcely detected in PTC cells (5-10%) and not found in control cells. CXCR4 expression correlated with the classical variant of PTC (p < 0.035) and extranodal extension (p < 0.010) in patients with LNM.
dc.description.abstractConclusions: Our data support the notion that CCR3, CCR7, and CXCR4 are increasingly expressed in tumor cells from PTC and that CXCR4 expression in PTC could be a potential marker for enhanced tumor aggressiveness.
dc.description.funderMillennium Nucleus on Immunology and Immunotherapy
dc.description.funderBiomedical Research Consortium
dc.fechaingreso.objetodigital2024-04-30
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1089/thy.2008.0432
dc.identifier.eissn1557-9077
dc.identifier.issn1050-7256
dc.identifier.pubmedidMEDLINE:19731977
dc.identifier.urihttps://doi.org/10.1089/thy.2008.0432
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75709
dc.identifier.wosidWOS:000269577900007
dc.information.autorucCiencias Biológicas;Bueno S;S/I;113541
dc.information.autorucMedicina;González HE;S/I;2927
dc.information.autorucCiencias Biológicas;Kalergis AM;S/I;90610
dc.information.autorucMedicina;Mosso L;S/I;88201
dc.information.autorucCiencias Biológicas;Riedel CA;S/I;88772
dc.information.autorucMedicina;Tapia G;S/I;12979
dc.information.autorucMedicina;Torres J;S/I;95391
dc.issue.numero9
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final965
dc.pagina.inicio957
dc.publisherMARY ANN LIEBERT, INC
dc.revistaTHYROID
dc.rightsregistro bibliográfico
dc.subjectLYMPH-NODE METASTASIS
dc.subjectCC-CHEMOKINE
dc.subjectEXTRACAPSULAR INVASION
dc.subjectPOOR-PROGNOSIS
dc.subjectCELL CARCINOMA
dc.subjectUP-REGULATION
dc.subjectIN-VIVO
dc.subjectCXCR4
dc.subjectINTERNALIZATION
dc.subjectPATTERN
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAltered Chemokine Receptor Expression in Papillary Thyroid Cancer
dc.typeartículo
dc.volumen19
sipa.codpersvinculados113541
sipa.codpersvinculados2927
sipa.codpersvinculados90610
sipa.codpersvinculados88201
sipa.codpersvinculados88772
sipa.codpersvinculados12979
sipa.codpersvinculados95391
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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