Introduction to network meta-analysis for evidence synthesis

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dc.catalogadorjlo
dc.contributor.authorGonzalez Xuriguera, Catalina Gracia
dc.contributor.authorVergara Merino, Laura
dc.contributor.authorGaregnani, Luis
dc.contributor.authorOrtiz Muñoz, Luis Eugenio
dc.contributor.authorMeza, Nicolás
dc.date.accessioned2024-06-27T19:33:01Z
dc.date.available2024-06-27T19:33:01Z
dc.date.issued2021
dc.description.abstractThis article belongs to a collaborative methodological series of narrative reviews about biostatistics and clinical epidemiology. The goal is to present basics concepts concerning the systematics reviews of multiple treatments comparisons with network meta-analysis. For clinical questions with several therapeutic alternatives to be compared, the central question is how to classify or rank their effectiveness (benefit and harm) to choose the best option. The network meta-analysis aims to answer questions related to the effectiveness and safety of comparing multiple treatments by the simultaneous analysis of results raised from direct and indirect comparisons. The network geometry is the general graphical representation of the network meta-analysis and allows to understand and assess the strength of comparisons. The network meta-analysis should check several assumptions to be valid, especially the transitivity assumption, which allows assuming that there are no systematic differences among the included comparisons, except their compared interventions. Thus, it is possible to know the relative therapeutic effectiveness of each pair of interventions included in the network meta-analysis and their ranking in terms of categorization. It has been proposed to use a modified Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) approach considering the distinctive features of network meta-analysis to assess the certainty of the evidence for each comparison and the ranking of interventions.
dc.fechaingreso.objetodigital2024-06-27
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.5867/medwave.2021.06.8315
dc.identifier.issn0717-6384
dc.identifier.pubmedidMEDLINE:34292922
dc.identifier.urihttps://doi.org/10.5867/medwave.2021.06.8315
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86888
dc.identifier.wosidWOS:000697024200001
dc.information.autorucEscuela de Medicina; Ortiz Muñoz, Luis Eugenio; 0000-0001-6449-2153; 121678
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final9
dc.pagina.inicio1
dc.revistaMedwave
dc.rightsacceso abierto
dc.subjectNetwork meta-analysis
dc.subjectSystematic reviews as topic
dc.titleIntroduction to network meta-analysis for evidence synthesis
dc.typeartículo
sipa.codpersvinculados121678
sipa.trazabilidadWOS;18-03-2022
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