Excision of an Unstable Pathogenicity Island in Salmonella enterica Serovar Enteritidis Is Induced during Infection of Phagocytic Cells

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dc.contributor.authorQuiroz, Tania S.
dc.contributor.authorNieto, Pamela A.
dc.contributor.authorTobar, Hugo E.
dc.contributor.authorSalazar Echegarai, Francisco J.
dc.contributor.authorLizana, Rodrigo J.
dc.contributor.authorQuezada, Carolina P.
dc.contributor.authorSantiviago, Carlos A.
dc.contributor.authorAraya, Daniela V.
dc.contributor.authorRiedel, Claudia A.
dc.contributor.authorKalergis, Alexis M.
dc.contributor.authorBueno, Susan M.
dc.date.accessioned2024-01-10T13:48:14Z
dc.date.available2024-01-10T13:48:14Z
dc.date.issued2011
dc.description.abstractThe availability of the complete genome sequence of several Salmonella enterica serovars has revealed the presence of unstable genetic elements in these bacteria, such as pathogenicity islands and prophages. This is the case of Salmonella enterica serovar Enteritidis (S. Enteritidis), a bacterium that causes gastroenteritis in humans and systemic infection in mice. The whole genome sequence analysis for S. Enteritidis unveiled the presence of several genetic regions that are absent in other Salmonella serovars. These regions have been denominated "regions of difference'' (ROD). In this study we show that ROD21, one of such regions, behaves as an unstable pathogenicity island. We observed that ROD21 undergoes spontaneous excision by two independent recombination events, either under laboratory growth conditions or during infection of murine cells. Importantly, we also found that one type of excision occurred at higher rates when S. Enteritidis was residing inside murine phagocytic cells. These data suggest that ROD21 is an unstable pathogenicity island, whose frequency of excision depends on the environmental conditions found inside phagocytic cells.
dc.description.funderFONDEYT
dc.description.funderIFS
dc.description.funderAnillo
dc.description.funderMillennium Nucleus on Immunology and Immunotherapy
dc.fechaingreso.objetodigital2024-05-07
dc.format.extent13 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1371/journal.pone.0026031
dc.identifier.issn1932-6203
dc.identifier.pubmedidMEDLINE:22039432
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0026031
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79347
dc.identifier.wosidWOS:000296507500028
dc.information.autorucCiencias Biológicas;Araya D;S/I;156009
dc.information.autorucCiencias Biológicas;Bueno S;S/I;113541
dc.information.autorucCiencias Biológicas;Kalergis A;S/I;90610
dc.information.autorucCiencias Biológicas;Nieto P;S/I;120888
dc.information.autorucCiencias Biológicas;Quiroz T;S/I;208015
dc.information.autorucCiencias Biológicas;Tobar H;S/I;181479
dc.issue.numero10
dc.language.isoen
dc.nota.accesoSin adjunto
dc.publisherPUBLIC LIBRARY SCIENCE
dc.revistaPLOS ONE
dc.rightsregistro bibliográfico
dc.subjectPRECISE EXCISION
dc.subjectVIBRIO-CHOLERAE
dc.subjectIDENTIFICATION
dc.subjectEVOLUTIONARY
dc.subjectRESISTANCE
dc.subjectINTEGRASE
dc.subjectMUTATIONS
dc.subjectDELETION
dc.subjectPROTEIN
dc.subjectTET
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExcision of an Unstable Pathogenicity Island in Salmonella enterica Serovar Enteritidis Is Induced during Infection of Phagocytic Cells
dc.typeartículo
dc.volumen6
sipa.codpersvinculados156009
sipa.codpersvinculados113541
sipa.codpersvinculados90610
sipa.codpersvinculados120888
sipa.codpersvinculados208015
sipa.codpersvinculados181479
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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