Carotid body chemosensory activity and ventilatory chemoreflexes in cats persist after combined cholinergic-purinergic block

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dc.contributor.authorReyes, E. P.
dc.contributor.authorFernandez, R.
dc.contributor.authorLarrain, C.
dc.contributor.authorZapata, P.
dc.date.accessioned2024-01-10T12:37:54Z
dc.date.available2024-01-10T12:37:54Z
dc.date.issued2007
dc.description.abstractAcetylcholine (ACh) and ATP have been proposed as excitatory co-transmitters operating at synapses between glomus cells and sensory nerve endings of the carotid body (CB). To test such hypothesis, we performed experiments on cats under pentobarbitone anesthesia and breathing spontaneously. Cholinergic and purinergic agonists and antagonists were given into one common carotid artery. Chemoreflex ventilatory changes initiated from the ipsilateral CB or chemosensory activity from the ipsilateral carotid nerve were recorded. Agonists ACh, nicotine, epibatidine, ATP, beta gamma-methylene-ATP and gamma S-ATP induced transient chemoreflex enhancements of ventilation or increased chemosensory activity. When given in combination, mecamylamine and suramin suppressed both nicotine- and ATP-induced ventilatory chemoreflexes or chemosensory responses. However, neither chemoreflex hyperventilation induced by brief hypoxic exposures or steady-state hypoxic levels, nor chemosensory excitation elicited by these maneuvers were eliminated. Asphyxia-induced chemosensory excitation was not reduced by combined blockade of ACh and ATP receptors. Furthermore, ventilatory or chemosensory depression evoked by 100% O-2 tests was unmodified, thus evidencing that basal chemosensory drive in normoxia was not suppressed by combined cholinergic-purinergic blockade. Therefore, although ACh and ATP may participate in chemoexcitation of the CB, their involvement fails to explain the origin of chemosensory discharges from synaptic transmission between glomus cells and chemosensory nerve endings of the CB. (c) 2006 Elsevier B.V. All rights reserved.
dc.fechaingreso.objetodigital09-04-2024
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.resp.2006.07.006
dc.identifier.issn1569-9048
dc.identifier.pubmedidMEDLINE:16956797
dc.identifier.urihttps://doi.org/10.1016/j.resp.2006.07.006
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76946
dc.identifier.wosidWOS:000245001500004
dc.information.autorucMedicina;Fernández R;S/I;99858
dc.information.autorucMedicina;Zapata P;S/I;98016
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final32
dc.pagina.inicio23
dc.publisherELSEVIER SCIENCE BV
dc.revistaRESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
dc.rightsacceso restringido
dc.subjectarterial chemoreceptors
dc.subjectcarotid body
dc.subjectcholinergic block
dc.subjectmecamylamine
dc.subjectpurinergic block
dc.subjectsuramin
dc.subjectventilatory chemoreflexes
dc.subjectNICOTINIC ACETYLCHOLINE-RECEPTORS
dc.subjectALPHA-BUNGAROTOXIN-BINDING
dc.subjectCHEMORECEPTORS IN-VIVO
dc.subjectRAT
dc.subjectATP
dc.subjectRELEASE
dc.subjectHYPOXIA
dc.subjectADENOSINE
dc.subjectCELLS
dc.subjectLOCALIZATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCarotid body chemosensory activity and ventilatory chemoreflexes in cats persist after combined cholinergic-purinergic block
dc.typeartículo
dc.volumen156
sipa.codpersvinculados99858
sipa.codpersvinculados98016
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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