DRD4 dopamine receptor alleles in Chilean students of different ethnic origin and its relation with the risk for attention deficit/hyperactivity disorder

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dc.contributor.authorRothhammer, Paula
dc.contributor.authorPaz Lagos, Liza
dc.contributor.authorEspinosa Parrilla, Yolanda
dc.contributor.authorAboitiz, Francisco
dc.contributor.authorRothhammer, Francisco
dc.date.accessioned2024-01-10T12:38:25Z
dc.date.available2024-01-10T12:38:25Z
dc.date.issued2012
dc.description.abstractBackground: Worldwide diversity of alleles of D4 receptor gene (DRD4), linked to attention deficit hyperactivity disorder (ADHD), is mostly the result of length and single nucleotide polymorphisms in a 48-bp tandem repeat (VNTR). Alleles containing from two (2R) to eleven (11R) repeats have been identified. The most common are 4R, 7R and 2R. Aim: To study the association of ADHD risk with DRD4 genotypes in Chilean students. Subjects and Methods: ADHD risk data were obtained through the abbreviated Conner's Scale for School Teachers in 66 Aymara children (11 cases and 55 controls), 91 Rapa-Nui children (60 cases ad 31 controls) and 96 children from a mixed urban population from Santiago (51 cases and 45 controls). DNA extracted from saliva was amplified by polymerase chain reaction (PCR) to genotype the DRD4 VNTR. Results: The distribution of DRD4 alleles reveals that, beneath the 4R allele, 7R exhibits the second highest frequencies in Aymara and Santiago children. In Polynesian children, 2R ranks after 4R. A statistically significant association between ADHD risk and 2R/4R genotype was identified in Polynesian children (p < 0.05; odds ratio = 3.7). Conclusions: Different DRD4 genotypes are associated with ADHD phenotype in Chilean populations, probably as a consequence of their initial colonization history. (Rev Med Chile 2012; 140: 1276-1281).
dc.fechaingreso.objetodigital2024-05-06
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4067/S0034-98872012001000006
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:23559284
dc.identifier.urihttps://doi.org/10.4067/S0034-98872012001000006
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77042
dc.identifier.wosidWOS:000311884500006
dc.information.autorucMedicina;Aboitiz F ;S/I;100165
dc.issue.numero10
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final1281
dc.pagina.inicio1276
dc.publisherSOC MEDICA SANTIAGO
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsregistro bibliográfico
dc.subjectAttention deficit disorder with hyperactivity
dc.subjectChild
dc.subjectDopamine D4
dc.subjectReceptors
dc.subjectDEFICIT HYPERACTIVITY DISORDER
dc.subject2-REPEAT ALLELE
dc.subjectD-4 RECEPTOR
dc.subjectHAPLOTYPE CHARACTERIZATION
dc.subjectGENE LOCUS
dc.subjectASSOCIATION
dc.subjectSELECTION
dc.subjectFREQUENCIES
dc.subjectRELEVANCE
dc.subjectSEEKING
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDRD4 dopamine receptor alleles in Chilean students of different ethnic origin and its relation with the risk for attention deficit/hyperactivity disorder
dc.typeartículo
dc.volumen140
sipa.codpersvinculados100165
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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