Interactions between H. pylori and the gastric microbiome: impact on gastric homeostasis and disease

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dc.catalogadorvzp
dc.contributor.authorSerrano Honeyman, Carolina Andrea
dc.contributor.authorHarris Diez, Paul Richard
dc.contributor.authorSmith, Phillip D.
dc.contributor.authorBimczok, Diane
dc.date.accessioned2024-01-17T19:33:13Z
dc.date.available2024-01-17T19:33:13Z
dc.date.issued2021
dc.description.abstractLike many seemingly inhospitable environments on our planet, the highly acidic human stomach harbors a diverse bacterial microflora. The best-known member of the human gastric flora, Helicobacter pylori, causes a number of gastric diseases, including peptic ulcer disease and gastric adenocarcinoma. In the absence of H. pylori infection, the gastric microbiota displays some features similar to the oral cavity with Firmicutes the most common phylum, followed by Proteobacteria and Bacteroidetes. When present, H. pylori dominates the gastric microbiome and reduces diversity and composition of other taxa. The composition of the gastric microbiome also is altered in the setting of proton pump inhibitor therapy and gastric neoplasia. This review summarizes foundational and recent studies that have investigated the composition of the human gastric microbiome in a variety of patient groups, with a focus on potential mechanisms involved in regulation of gastric microbial community structure.
dc.description.funderNational Institutes of Health
dc.description.funderMontana Agricultural Experiment Station USDA/NIFA Hatch project
dc.description.funderUAB School of Medicine Award
dc.description.funderUAB Microbiome Research Center Award
dc.description.funderDiGregorio Family Foundation
dc.description.funderMontana INBRE pilot award
dc.description.funderCONICYT-PIA ANILLO
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.cophys.2021.04.003
dc.identifier.eissn2468-8673
dc.identifier.pubmedidMEDLINE:34113748
dc.identifier.urihttps://doi.org/10.1016/j.cophys.2021.04.003
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80558
dc.identifier.wosidWOS:000657692200009
dc.information.autorucEscuela de Medicina; Serrano Honeyman, Carolina Andrea; 0000-0001-5523-0637; 15296
dc.information.autorucEscuela de Medicina; Harris Diez, Paul Richard; 0000-0001-6226-0957; 80706
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final64
dc.pagina.inicio57
dc.publisherELSEVIER
dc.revistaCURRENT OPINION IN PHYSIOLOGY
dc.rightsacceso restringido
dc.subjectHelicobacter-Pylori
dc.subjectGut microbiota
dc.subjectInfection
dc.subjectStomach
dc.subjectCancer
dc.subjectInflammation
dc.subjectDysbiosis
dc.subjectChildren
dc.subject.ddc610
dc.subject.deweyMedicina y salud
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleInteractions between H. pylori and the gastric microbiome: impact on gastric homeostasis and disease
dc.typeartículo
dc.volumen21
sipa.codpersvinculados15296
sipa.codpersvinculados80706
sipa.trazabilidadWOS;18-03-2022
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